| 侯建春,孙妍,陈薇.血清趋化因子 2、8-羟基脱氧鸟苷水平与抑郁症认知功能损害的关系[J].安徽医药,2026,30(5):994-998. |
| 血清趋化因子 2、8-羟基脱氧鸟苷水平与抑郁症认知功能损害的关系 |
| The relationship between serum CCL2, 8-OHdG levels and cognitive impairment in patients with depression |
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| DOI：10.3969/j.issn.1009-6469.2026.05.029 |
| 中文关键词: 抑郁症 血清趋化因子 2 8-羟基脱氧鸟苷 认知功能损害 |
| 英文关键词: Depression Serum chemokine CC motif ligand-2 8-hydroxydeoxyguanosine Cognitive impairment |
| 基金项目:河北省医学科学研究课题项目( 20231851) |
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| 中文摘要: |
| 目的探讨抑郁症病人血清趋化因子 2(CCL2)、 8-羟基脱氧鸟苷( 8-OHdG)水平与认知功能损害( CI)的关系。方法纳入 2021年 4月至 2024年 4月在开滦精神卫生中心治疗的 422例抑郁症病人为抑郁症组，基于简易智力状态检查量表(MMSE)将其分为认知正常组( n=275)和认知损害组( n=147)，另选 400例同期在开滦精神卫生中心进行体检健康者作为健康组。采用酶联免疫吸附分析( ELISA)对各组血清 CCL2与 8-OHdG水平进行定量检测； Pearson法分析抑郁症病人血清 CCL2、8-OHdG水平与汉密尔顿抑郁量表( HAMD)、 MMSE评分之间的关联性； logistic回归分析影响抑郁症病人 CI发生的因素；受试者操作特征曲线( ROC曲线)预测抑郁症病人血清 CCL2与 8-OHdG水平对其 CI发生的效能。结果与健康组相比，抑郁症组病人血清 CCL2［( 334.41±61.47)ng/L比( 241.65±46.93)ng/L］、 8-OHdG［(58.97±10.46)ng/L比( 36.54±8.68)ng/L］水平显著升高( P<0.05)；认知损害组病人血清 CCL2、8-OHdG水平及 HAMD评分较认知正常组显著升高，而 MMSE评分较认知正常组显著降低(P<0.05)。抑郁症病人血清 CCL2、8-OHdG水平与 HAMD总评分呈正相关( r=0.51、0.51，P<0.05)与 MMSE评分呈负相关( r= .0.45、.0.43，P<0.05)。血清 CCL2、8-OHdG水平及 HAMD总评分是病人 CI发生的影响因素(P<0.05 )。抑郁症病人血清 CCL2、 8-OHdG单独及联合预测其 CI发生的曲线下面积( AUC)分别为［ 0.77，95%CI:(0.73，0.81)； 0.77，95%CI:(0.72，0.81)； 0.86， 95%CI:(0.82，0.89)］；灵敏度分别为 70.75%、66.67%、89.12%，特异度分别为 83.27%、84.36%、79.64%；联合预测效能优于单独检测( Z二者联合 -CCL2=3.15，Z二者联合 -8-OHdG=3.73；P<0.05)。结论抑郁症病人血清 CCL2、8-OHdG水平升高与其 CI发生有关，二者联合预测病人 CI发生具有更高的准确性。 |
| 英文摘要: |
| Objective To investigate the relationship between serum chemokine CC motif ligand-2 (CCL2) and 8-hydroxydeoxyguano. sine (8-OHdG) levels and cognitive impairment (CI) in patients with depression.Methods From April 2021 to April 2024, 422 pa.tients with depression treated in Kailuan Mental Health Center were included as the depression group. Based on the Mini-Mental State Examination (MMSE), they were assigned to a cognitive normal group (n=275) and a cognitive impairment group (n=147). Another 400healthy people who underwent physical examination in Kailuan Mental Health Center during the same period were selected as thehealthy control group. Enzyme linked immunosorbent assay (ELISA) was performed to quantify serum CCL2 and 8-OHdG levels in each group. Pearson correlation analysis was used to examine the correlation between serum CCL2, 8-OHdG levels and Hamilton DepressionRating Scale (HAMD), MMSE scores in patients with depression. Logistic regression was used to analyze the risk factors for CI in pa.tients with depression. The receiver operating characteristic curve (ROC curve) was used to predict the efficacy of serum CCL2 and 8-OHdG levels on the occurrence of CI.Results Compared with the healthy control group, the serum levels of CCL2 [(334.41±61.47) ng/ L vs. (241.65±46.93) ng/L] and 8-OHdG [(58.97±10.46) ng/L vs. (36.54±8.68) ng/L] in the depression group were significantly higher (P <0.05). The serum levels of CCL2 and 8-OHdG and HAMD total score in the cognitive impairment group were prominently higher thanthose in the cognitive normal group, while the MMSE score was obviously lower than that in the cognitive normal group (P<0.05). The serum CCL2 and 8-OHdG levels in patients with depression were positively correlated with HAMD total score (r=0.51, 0.51, P<0.05) and negatively correlated with MMSE score (r=.0.45,.0.43, P<0.05). Serum CCL2 and 8-OHdG levels and HAMD total score were in. fluential factors for the occurrence of CI in patients (P<0.05). The areas under the curve (AUC) of serum CCL2 and 8-OHdG alone and in combination in predicting the occurrence of CI in patients with depression were [0.77, 95%CI:(0.73, 0.81); 0.77, 95%CI:(0.72, 0.81), and 0.86, 95%CI: (0.82, 0.89)], respectively. The sensitivities and specificities were 70.75%, 66.67%, and 89.12%, and 83.27%,84.36%, and 79.64%, respectively. The combined prediction performance was better than that of individual detection (Zcombination-CCL2 = 3.15, Zcombination-8-OHdG=3.73, P<0.05).Conclusion The elevated serum CCL2 and 8-OHdG in patients with depression are related to theoccurrence of CI, and the combination of the two has a higher accuracy in predicting the occurrence of CI in patients. |
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