| 刘芳艳,岳爱民,王海溥,等.术前中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值联合第三腰椎骨骼肌指数对原发性肝癌根治性切除术后早期复发的预测价值[J].安徽医药,2026,30(5):1013-1018. |
| 术前中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值联合第三腰椎骨骼肌指数对原发性肝癌根治性切除术后早期复发的预测价值 |
| Analysis of the prognostic value of preoperative NLR, PLR and L3SMI in predicting early recurrence of hepatocellular carcinoma after surgery |
| |
| DOI：10.3969/j.issn.1009-6469.2026.05.033 |
| 中文关键词: 原发性肝癌 肝癌根治性切除 肌肉减少症 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 第三腰椎骨骼肌指数 早期复发 |
| 英文关键词: Primary carcinoma of liver Radical resection of hepatocellular carcinoma Sarcopenia Neutrophil-to-lymphocyte ra tio Platelet-to-lymphocyte ratio L3 skeletal muscle index Early recurrence |
| 基金项目: |
|
| 摘要点击次数: 248 |
| 全文下载次数: 76 |
| 中文摘要: |
| 目的探讨术前中性粒细胞与淋巴细胞比值( NLR)、血小板与淋巴细胞比值( PLR)联合第三腰椎骨骼肌指数( L3SMI)对原发性肝癌( HCC)根治性切除术后早期复发的预测价值。方法选取新乡医学院第四临床学院 2020年 1月至 2021年 12月收治的 112例接受根治性切除术的原发性肝癌病人，在接受手术后的 2年内对病人进行随访，并记录复发情况，以此将病人分为复发和未复发两组，比较并分析两组病人术前 NLR、PLR及 L3SMI与早期复发的关系。结果 112例病人中，复发组和未复发组人数分别为 43例和 69例，分别占随访总人数的 38.4％及 61.6％，复发组的 NLR(4.44±0.55比 1.91±0.08)、PLR(154.94±8.01比 101.79±4.37)的平均水平均高于未复发组( P<0.05)； L3SMI平均水平均低于未复发组［( 36.53±6.74)cm2/m2比( 38.95±6.74) cm2/m2］。经过单因素分析，肝癌病人术后早期复发与肿瘤长径、门静脉癌栓情况、甲胎蛋白( AFP)水平、包膜完整程度、 NLR、 PLR、L3SMI显著相关(P<0.05)；而在多因素分析中， NLR、PLR、L3SMI被确认为独立的危险因素，对肝癌术后早期复发有重要影响( P<0.05)。受试者操作特征曲线( ROC曲线)分析结果显示， NLR、PLR、L3SMI及三项指标联合预测肝癌切除术后早期复发的 ROC曲线下面积( AUC)分别为 0.88，95%CI:(0.80，0.95)(P<0.001)、0.73，95%CI:(0.64，0.82)(P<0.001)0.61，95%CI:(0.50，0.72)(P=0.051)和 0.92，95%CI:(0.87，0.98)(P<0.001)。结论术前 NLR、PLR、L3SMI可用于预测肝癌根切除术后早期复发，且三者联合检测可能有更高的预测价值。治性、 |
| 英文摘要: |
| Objective To investigate the predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lympho. cyte ratio (PLR), and third lumbar skeletal muscle index (L3SMI) for early recurrence after radical resection of hepatocellular carcinoma (HCC).Methods A total of 112 patients with primary hepatocellular carcinoma who underwent radical resection at the Fourth ClinicalCollege of Xinxiang Medical University from January 2020 to December 2021 were selected. Patients were followed up for two yearspostoperatively, and recurrence status was recorded to categorize patients into recurrence and non-recurrence groups. The relationships between preoperative NLR, PLR, L3SMI, and early recurrence were compared and analyzed.Results Among the 112 patients, there were 43 cases in the recurrence group and 69 cases in the non-recurrence group, accounting for 38.4% and 61.6% of the total follow-up population, respectively. The mean levels of NLR (4.44±0.55 vs. 1.91±0.08) and PLR (154.94±8.01 vs. 101.79±4.37) in the recurrence group were significantly higher than those in the non-recurrence group (P<0.05); meanwhile, the mean L3SMI level was lower in the re. currence group [(36.53±6.74)cm2/m2 vs. (38.95±6.74)cm2/m2]. Univariate analysis revealed that early recurrence of HCC was significant.ly associated with tumor diameter, portal vein tumor thrombus, alpha fetal protein (AFP) level, capsule integrity, NLR, PLR, and L3SMI (P<0.05). In multivariate analysis, NLR, PLR, and L3SMI were confirmed as independent risk factors influencing early recurrence after |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
