| 曹露,赵阳.不同频次高能红光照射联合普瑞巴林治疗老年带状疱疹后遗神经痛的随机对照研究[J].安徽医药,2026,30(5):1018-1022. |
| 不同频次高能红光照射联合普瑞巴林治疗老年带状疱疹后遗神经痛的随机对照研究 |
| Different frequencies of high-energy red light combined with pregabalin for the treatment of postherpetic neuralgia in older people with herpes zoster : a randomised controlled study |
| |
| DOI：10.3969/j.issn.1009-6469.2026.05.034 |
| 中文关键词: 神经痛，带状疱疹后 普瑞巴林 红光 细胞因子 |
| 英文关键词: Neuralgia,postherpetic Pregabalin Red light Cytokines |
| 基金项目: |
|
| 摘要点击次数: 248 |
| 全文下载次数: 73 |
| 中文摘要: |
| 目的评估两种频次高能红光照射联合普瑞巴林治疗老年带状疱疹后遗神经痛( PHN)的临床疗效及对血清炎症细胞因子的影响。方法 2020年 6月至 2021年 9月在中国人民解放军南部战区总医院接受治疗的 90例老年 PHN病人，采用随机数字表法被分为无光照组、低频次组和高频次组，每组各 30例。三组使用的基础药物均为普瑞巴林、甲钴胺，低频次组每 2天红光照射为 1次，高频次组为每天 1次，两组红光均垂直照射疼痛区，每次治疗持续 20 min。以治疗前、治疗后 1周、治疗后 4周为时间点，评估不同时间点时的量表评分［视觉模拟量表评分( VAS)焦虑自评量表评分(SAS)、阿森斯失眠量表(AIS)］和血清因子含量［血清白细胞介素 -2(IL-2)、白细胞介素 -6(IL-6)和肿瘤坏死、因子 α(TNF-α)］。结果三组病人治疗后 1周、 4周时 VAS评分、 SAS评分及 AIS评分均比治疗前显著改善( P<0.05)。在治疗后 1周时，高频次组的 VAS评分为( 3.67±0.32)分，显著低于低频次组的( 4.06±0.67)分及无光照组的(5.76±0.72)分；在治疗后 4周时，高频次组 VAS评分为( 1.39±0.43)分，显著低于低频次组的( 2.57±0.53)分及无光照组的( 3.92±1.13)分(均 P<0.05)。 SAS与 AIS评分呈现相似趋势。三组病人治疗 4周时血清 IL-2较治疗前有显著升高，高频次组升至( 8.97±0.72)ng/L，显著高于低频次组的( 8.17±0.81)ng/L及无光照组的(6.81±1.36)ng/L(均 P<0.05)；同时， IL-6和 TNF-α水平较治疗前显著下降，高频次组分别降至(4.38±0.20)ng/L和( 22.73±2.24)mg/L，均显著低于低频次组［(4.63±0.15)ng/L和( 25.72±3.03)mg/L］和无光照组［( 5.14±0.35)ng/L和( 28.21±4.20)mg/L］(均 P<0.05)。结论两种频次高能红光联合普瑞巴林治疗老年 PHN均能获得满意疗效，并能有效缓解病人焦虑抑郁状态、明显改善睡眠质量，但高频次红光照射疗效更优。其机制可能是红光照射对血清炎症细胞因子表达具有一定调节作用。 |
| 英文摘要: |
| Objiective To assess the clinical effectiveness of high-energy red light irradiation at two different frequencies, combinedwith pregabalin, in treating postherpetic neuralgia (PHN) in elderly patients with herpes zoster, as well as to investigate the impact onserum inflammatory cytokines.Methods Ninety elderly patients with herpes zoster PHN treated at the General Hospital of SouthernTheater Command of the Chinese People's Liberation Army from June 2020 to September 2021 were randomly assigned to threegroups: no-light, low-frequency, and high-frequency, with 30 patients in each group. The three groups used pregabalin and methylcobal.amin as their basic drugs. Red light irradiation was administered once every two days in the low-frequency group and once daily in the high-frequency group, with each session lasting 20 minutes. The pain area was irradiated vertically with red light in both groups. Thestudy assessed scale scores, including the visual analog scale (VAS) score, self-assessment scale for anxiety (SAS) score, and ascens in. somnia scale (AIS), as well as serum factor levels, including serum interleukin-2 (IL-2), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), at three different time points: pre-treatment, 1 week post-treatment, and 4 weeks post-treatment.Results The VAS,SAS, and AIS scores of the three groups of patients were significantly improved at 1 week and 4 weeks after treatment compared to be.fore treatment (P<0.05). At 1 week after treatment, the VAS score in the high-frequency group was (3.67±0.32) points, which was signif. icantly lower than that in the low-frequency group (4.06±0.67) points and the no-light group (5.76±0.72) points. At 4 weeks after treat. ment, the VAS score in the high-frequency group was (1.39±0.43) points, significantly lower than that in the low-frequency group (2.57± 0.53) points and the no-light group (3.92±1.13) points (all P<0.05). The SAS and AIS scores showed similar trends. Serum IL-2 levels were significantly increased in all three groups at 4 weeks after treatment compared to before treatment, with the high-frequency group rising to (8.97±0.72)ng/L, significantly higher than the low-frequency group (8.17±0.81)ng/L and the no-light group (6.81±1.36)ng/L (all P<0.05). Meanwhile, IL-6 and TNF-α levels were significantly decreased compared to before treatment, with the high-frequency group dropping to (4.38±0.20)ng/L and (22.73±2.24)mg/L, respectively, which were significantly lower than those in the low-frequency group [(4.63±0.15)ng/L and (25.72±3.03)mg/L] and the no-light group [(5.14±0.35)ng/L and (28.21±4.20)mg/L] (all P<0.05). Conclu. sions Both frequencies of high-energy red light combined with pregabalin can achieve satisfactory efficacy in treating PHN in the el.derly. This treatment can effectively alleviate anxiety and depression and significantly improve sleep quality. However, high-frequencyred light irradiation appears to be more effective. The mechanism may involve the regulatory effect of red light irradiation on the expres.sion of serum inflammatory cytokines. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
