| 刘爱国,陈湘磊,李鑫.伴中枢浸润的原发心脏弥漫大 B细胞淋巴瘤 1例并文献复习[J].安徽医药,2026,30(5):1037-1039. |
| 伴中枢浸润的原发心脏弥漫大 B细胞淋巴瘤 1例并文献复习 |
| Primary cardiac diffuse large B-cell lymphoma with central nervous system involvement: a case report and literature review |
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| DOI：10.3969/j.issn.1009-6469.2026.05.038 |
| 中文关键词: 心脏肿瘤 淋巴瘤，大 B细胞，弥漫性 ZR2方案 中枢浸润 |
| 英文关键词: Heart neoplasms Lymphoma,large b-cell,diffuse ZR2 regimen Central nervous system involvement |
| 基金项目:福建省卫生健康科技计划项目( 2020GGA035) |
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| 中文摘要: |
| 目的探讨伴中枢浸润的原发心脏弥漫大 B细胞淋巴瘤的临床特征、诊断与鉴别、治疗、预后，并复习相关文献。方法对就诊于潍坊市益都中心医院的 52岁女性病人进行回顾性分析。结果经术前心脏彩超、心脏外科手术、术后病理，诊断为原发心脏弥漫大 B细胞淋巴瘤，术后行 PET-CT检查发现有中枢神经系统浸润，行 2周期泽布替尼 +来那度胺 +利妥昔单抗(ZR2)方案治疗后，颅内病灶消失。结论 ZR2方案可有效治疗伴中枢浸润的原发心脏弥漫大 B细胞淋巴瘤。 |
| 英文摘要: |
| Objective To explore the clinical features, diagnosis, differential diagnosis, treatment, and prognosis of primary cardiac diffuse large B-cell lymphoma (PCDLBCL) with central nervous system (CNS) involvement, and to review the relevant literature.Meth. ods A retrospective analysis was conducted on a 52-year-old female patient treated at Yidu Central Hospital of Weifang. Results The patient was diagnosed with PCDLBCL, as confirmed by preoperative echocardiography, cardiac surgery, and postoperative patholo.gy. Postoperative PET-CT revealed CNS involvement. After two cycles of treatment with the ZR2 regimen (zanubrutinib, lenalidomide,and rituximab), CNS lesions resolved.Conclusion The ZR2 regimen is an effective therapy for PCDLBCL with CNS involvement. |
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