| 胡琴,吉兆宁,陈传荣,等.靶向ACLY重塑肿瘤免疫微环境：从代谢调控到临床转化[J].安徽医药,待发表. |
| 靶向ACLY重塑肿瘤免疫微环境：从代谢调控到临床转化 |
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| 投稿时间：2026-06-08 录用日期：2026-08-15 |
| DOI： |
| 中文关键词: 三磷酸腺苷柠檬酸裂解酶 肿瘤代谢 免疫微环境 免疫检查点抑制剂 转化医学 |
| 英文关键词: |
| 基金项目:国家自然科学基金项目（面上项目 基金号 82373294） |
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| 中文摘要: |
| 【】 肿瘤代谢重编程与免疫逃逸是恶性肿瘤发生发展的核心特征。三磷酸腺苷柠檬酸裂解酶(ATP citrate lyase, ACLY)作为连接碳水代谢与表观遗传调控的关键枢纽,在多种实体瘤中呈异常高表达。近期研究表明,ACLY不仅通过提供乙酰辅酶A维持肿瘤细胞的代谢需求,还通过组蛋白乙酰化修饰调控免疫检查点基因的表达,介导肿瘤免疫逃逸。本文旨在综述ACLY在调节肿瘤免疫微环境中的关键作用,探讨靶向ACLY协同免疫检查点抑制剂克服耐药的分子机制,并就未来临床转化面临的挑战与策略进行展望。 |
| 英文摘要: |
| 【】Tumor metabolic reprogramming and immune evasion are central characteristics of malignant tumor development. Adenosine triphosphate citrate lyase (ATP citrate lyase, ACLY), serving as a critical link between carbohydrate metabolism and epigenetic regulation, exhibits abnormally high expression in various solid tumors. Recent studies have demonstrated that ACLY not only meets the metabolic demands of tumor cells by providing acetyl-CoA but also regulates the expression of immune checkpoint genes through histone acetylation modifications, thereby mediating tumor immune evasion.This review aims to summarize the pivotal role of ACLY in regulating the tumor immune microenvironment, investigate the molecular mechanisms underlying the synergistic effect of ACLY-targeting therapies combined with immune checkpoint inhibitors in overcoming drug resistance, and outline future challenges and strategies for clinical translation. |
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