| 陆云圻,李晓莹,周正.伴失眠患者疗效、血清神经递质指标及生活质量的影响[J].安徽医药,待发表. |
| 伴失眠患者疗效、血清神经递质指标及生活质量的影响 |
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| 投稿时间：2026-06-08 录用日期：2026-08-06 |
| DOI： |
| 中文关键词: 偏头痛 失眠 针刺 耳穴埋豆 疗效 机制 |
| 英文关键词: |
| 基金项目:1.2022年度上海市卫生健康委员会中医药科研项目(2022QN016)；2.2024年上海市第五人民医院“曙光人才”培养计划项目(2024WYRCSG05)3.复旦大学附属上海市第五人民医院院级医学重点专科建设计划项目(2025WYZDZK03) |
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| 中文摘要: |
| 目的 探究针刺联合耳穴埋豆治疗偏头痛伴失眠的疗效及对患者血清神经递质指标[5-羟色胺（5-HT）、P物质（SP）、降钙素基因相关肽（CGRP）、β-内啡肽（β-EP）、多巴胺（DA）]及生活质量的影响。方法 选取2024年2月至2025年12月就诊的偏头痛伴失眠患者126例，随机分为联合组（63例）与对照组（63例）。对照组行针刺治疗，联合组行针刺联合耳穴埋豆治疗。对比两组失眠疗效、治疗前后头痛症状、匹兹堡睡眠质量指数量表（PSQI）评分、血清各指标及生活质量量表-36（SF-36）评分，并统计不良反应发生率。结果 联合组总有效率为93.65%（59/63），比对照组的80.95%（51/63）显著高（P＜0.05）。对比治疗前，两组治疗后头痛发作频率/持续时间、中医证候积分、头痛视觉模拟评分及PSQI评分均明显下降（P＜0.05），联合组治疗后上述指标均明显低于对照组（P＜0.05）。对比治疗前，两组治疗后血清5-HT、β-EP及DA均明显上升且联合组治疗后均高于对照组（P＜0.05），SP、CGRP明显下降且联合组治疗后均低于对照组（P＜0.05）。联合组治疗后SF-36量表中躯体疼痛、精力、一般健康状况、生理职能评分均明显大于对照组（P＜0.05）。两组均无不良反应出现。结论 针刺联合耳穴埋豆治疗偏头痛伴失眠安全有效，能明显改善患者头痛及失眠症状，提升其生活质量，其机制可能与上调5-HT、β-EP、DA，下调SP、CGRP水平有关，但确切因果关系需进一步验证。 |
| 英文摘要: |
| Objective To explore the efficacy of acupuncture combined with auricular point bean embedding in the treatment of migraine complicated with insomnia and its influence on the level of serum neurotransmitter indicators [5-hydroxytryptamine (5-HT), Substance P (SP), β-Endorphin (β-EP), Dopamine (DA), calcitonin gene-related peptide (CGRP)], and the quality of life. Methods A total of 126 patients with migraine and insomnia from February 2024 to December 2025 were chosen and randomly divided into the combined group (n=63, acupuncture + auricular point bean embedding) and the control group (n=63, acupuncture). The insomnia efficacy, headache symptoms, Pittsburgh Sleep Quality Index Scale (PSQI) scores, serum indicators and short form-quality of life scale 36 (SF-36) scores before and after treatment were compared, and the incidence of adverse reactions was counted. Results The total effective rate in the combined group was 93.65% (59/63), which was higher than that in the control group [80.95% (51/63)] (P < 0.05). Compared with those before treatment, the frequency/duration of headache attack, TCM syndrome score, visual analogue score of headaches and PSQI scores significantly decreased in both groups after treatment (P < 0.05), and the above indexes in the combined group were significantly lower (P < 0.05). Compared with those before treatment, serum 5-HT, β-EP and DA in the two groups significantly increased after treatment, and those in the combined group were higher, while SP and CGRP significantly decreased, and those in the combined group were lower (P < 0.05). The scores of bodies pain, energy, general health status and physiological function in SF scale of the combined group were significantly higher than those of the control group after treatment (P < 0.05). No adverse reactions occurred in both groups. Conclusions Acupuncture combined with auricular point bean embedding in the treatment of migraine complicated with insomnia is safe and effective, can significantly improve the symptoms of headache and insomnia, and improve their quality of life, the mechanism may be related to up-regulation of 5-HT, β-EP, DA, and down-regulation of SP, CGRP levels. However, the exact causal relationship needs to be further verified. |
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