| 吴嘉仪,杨建平.基于骨免疫探讨青藤碱防治炎症性骨病 作用与机制的研究进展[J].安徽医药,待发表. |
| 基于骨免疫探讨青藤碱防治炎症性骨病 作用与机制的研究进展 |
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| 投稿时间：2026-06-09 录用日期：2026-08-03 |
| DOI： |
| 中文关键词: 青藤碱 骨免疫调控 炎症性骨病 中西医结合 |
| 英文关键词: |
| 基金项目:江苏省中医药管理局科技发展专项基金(MS2024073)；常州市科学技术局科技计划项目(CJ20241122)；江苏省研究生科研与实践创新计划(SJCX25_0964) |
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| 中文摘要: |
| 炎症性骨病是一类由免疫炎症介导、以骨代谢异常为特征的疾病。青藤碱（sinomenine, SIN）是从中药青风藤中提取出的异喹啉类单体，具有抗炎、镇痛和免疫抑制等作用。近年来骨免疫调控理论的不断发展为SIN防治炎症性骨病的研究提供了新的思路。本文从骨免疫学视角出发，综述SIN在炎症性骨病中的研究进展，探究其通过调控T细胞活化、促进巨噬细胞极化及抑制多条信号通路，发挥祛邪与扶正双重效应，并初步探讨SIN在不同疾病中的表现出的靶点选择性差异与中医辨证论治思想之间的潜在联系。本文也针对安全性、当前研究不足进行讨论并提出展望，旨在为SIN的深入研究和临床转化提供理论依据，并为中药现代化研究提供参考。 |
| 英文摘要: |
| Inflammatory bone diseases are a group of disorders mediated by immune-mediated inflammation and characterized by aberrant bone metabolism. Sinomenine (SIN), an isoquinoline alkaloid isolated from Sinomenium acutum, a traditional Chinese medicinal plant, possesses anti-inflammatory, analgesic, and immunosuppressive properties. Recent advances in osteoimmunological theory have provided novel perspectives for the study of SIN in the prevention and treatment of inflammatory bone diseases. From an osteoimmunological perspective, this review summarizes the current research progress on SIN in inflammatory bone diseases, focusing on its dual effects of "dispelling pathogens and strengthening vital qi"—specifically, suppressing pathological inflammation and promoting tissue homeostasis—through regulating T cell activation, promoting macrophage polarization, and inhibiting multiple signaling pathways. Furthermore, we preliminarily explore the potential correlation between the disease-dependent target selectivity of SIN and the principles of TCM syndrome differentiation-based therapy. The safety profile, current limitations, and unresolved issues are also critically discussed, and future research directions are proposed. This review aims to provide a theoretical basis for further mechanistic investigation and clinical translation of SIN, while also serving as a reference for the modernization of traditional Chinese medicine research. |
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