| 郝婷婷.血清NLRC4、ATG10、CX3CL1水平对溃疡性结肠炎患儿预后的预测价值[J].安徽医药,待发表. |
| 血清NLRC4、ATG10、CX3CL1水平对溃疡性结肠炎患儿预后的预测价值 |
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| 投稿时间：2026-06-25 录用日期：2026-08-21 |
| DOI： |
| 中文关键词: 溃疡性结肠炎 NLRC4 ATG10 CX3CL1 病情 |
| 英文关键词: |
| 基金项目:2021年度河北省医学科学研究课题计划（编号：20210072） |
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| 摘要点击次数: 24 |
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| 中文摘要: |
| 目的:探究溃疡性结肠炎(UC)患儿血清NOD样受体家族蛋白4(NLRC4)、自噬相关基因10(ATG10)、C-X3-C趋化因子配体1(CX3CL1)水平与病情、预后的关系。方法:本研究纳入2020年6月至2023年6月期间在本院确诊的UC患儿共150例作为UC组,另选择本院同期150例健康儿童为对照组。采用ELISA测定血清NLRC4、ATG10、CX3CL1表达水平；采用Logistic回归分析影响UC患儿预后的因素；ROC评估血清NLRC4、ATG10、CX3CL1对UC患儿预后的预测效能。结果:与对照组相比,UC组血清NLRC4水平降低(P＜0.05),ATG10、CX3CL1水平升高(P＜0.05)。随着病情程度的加重,轻度、中度、重度UC患儿血清NLRC4水平逐渐降低(P＜0.05),ATG10、CX3CL1水平逐渐升高(P＜0.05)。复发组与未复发组病情程度差异有统计学意义(P＜0.05)。与未复发组相比,复发组血清NLRC4水平降低(P＜0.05),ATG10、CX3CL1水平升高(P＜0.05)。血清NLRC4、ATG10、CX3CL1、病情程度是UC患儿预后的影响因素(P＜0.05)。血清NLRC4、ATG10、CX3CL1三者联合预测UC患儿预后的AUC高于单独预测(Z三者联合-NLRC4=3.855,P=0.001、Z三者联合-ATG10=4.564,P＜0.001、Z三者联合-CX3CL1=3.680,P＜0.001)。结论:UC患儿血清NLRC4水平降低,ATG10、CX3CL1水平升高,与病情程度有关,三者联合可显著提高UC患儿预后评估价值。 |
| 英文摘要: |
| Objective: To explore the relationship between levels of serum NOD-like receptor family CARD domain-containing 4 (NLRC4), autophagy related gene 10 (ATG10), and C-X3-C motif chemokine ligand 1 (CX3CL1) with the severity and prognosis of children with ulcerative colitis (UC). Methods: This study included a total of 150 children diagnosed with UC in our hospital between June 2020 and June 2023 as the UC group. Another 150 healthy children in our hospital were served as the control group. ELISA was used to measure serum NLRC4, ATG10, and CX3CL1. Logistic regression was used to explore the factors affecting the prognosis of children with UC. Moreover, ROC was used to evaluate the predictive efficacy of serum NLRC4, ATG10, and CX3CL1 for the prognosis of children with UC. Results: Compared with the control group, the UC group had lower serum NLRC4 (P<0.05) and higher ATG10 and CX3CL1 (P<0.05). As the severity worsened, the serum NLRC4 in children with mild, moderate, and severe UC gradually decreased (P<0.05), while ATG10 and CX3CL1 gradually increased (P<0.05). There was a statistical difference in the disease severity between the recurrent group and the non recurrent group (P<0.05). Compared with the non recurrent group, the recurrent group had lower serum NLRC4 (P<0.05) and higher ATG10 and CX3CL1 (P<0.05). Serum NLRC4, ATG10, CX3CL1, and disease severity were prognostic factors in children with UC (P<0.05). The AUC of predicting the prognosis of children with UC by combining serum NLRC4, ATG10, and CX3CL1 was higher than the individual predictions (Z combination - NLRC4=3.855, P=0.001, Z combination - ATG10=4.564, P<0.001, Z combination - CX3CL1=3.680, P<0.001). Conclusion: The serum NLRC4 in children with UC is decreased, while ATG10 and CX3CL1 are increased, which is related to the disease severity. The combination of the three can prominently improve the prognostic evaluation value of children with UC. |
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