| 刘素彬.主动脉内球囊反搏早期联合体外心肺复苏对院外心脏骤停患者自主循环恢复及预后的影响：一项前瞻性随机对照研究[J].安徽医药,待发表. |
| 主动脉内球囊反搏早期联合体外心肺复苏对院外心脏骤停患者自主循环恢复及预后的影响：一项前瞻性随机对照研究 |
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| 投稿时间：2026-07-03 录用日期：2026-08-18 |
| DOI： |
| 中文关键词: 体外心肺复苏 主动脉内球囊反搏 院外心脏骤停 自主循环恢复 预后 |
| 英文关键词: |
| 基金项目:安阳市2025年科技计划项目，2025C01SF116 |
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| 摘要点击次数: 19 |
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| 中文摘要: |
| 目的 探讨体外心肺复苏(ECPR)联合主动脉内球囊反搏(IABP)早期对院外心脏骤停患者自主循环恢复、预后的影响,期望为临床治疗院外心脏骤停患者提供一定的参考依据。方法 采用前瞻性研究,选择2025年1月至2026年3月安阳市人民医院收治的118例院外心脏骤停患者,以随机数字表法分为观察组(n=59)与对照组(n=59)。对照组采用ECPR治疗,观察组在对照组的基础上采用IABP早期治疗(ECPR治疗后60分钟内进行IABP治疗)。对比两组平均动脉压、心输出量、心脏指数、自主循环恢复情况、乳酸清除率、尿量、预后及并发症。结果 复苏后3d,两组平均动脉压均升高(P＜0.05)；复苏后4h、复苏后3d,观察组平均动脉压高于对照组(P＜0.05)；治疗后,两组的心输出量、心脏指数均升高(P＜0.05),且观察组更高(P＜0.05)。观察组自主循环恢复率高于对照组(P＜0.05)；治疗后,两组乳酸清除率、尿量均升高(P＜0.05),且观察组更高(P＜0.05)。观察组神经功能预后良好率、24小时存活率、30天生存率高于对照组(P＜0.05)。两组并发症总发生率比较,差异无统计学意义(P＞0.05)。结论 ECPR联合IABP早期可提高院外心脏骤停患者自主循环恢复率,改善平均动脉压、心输出量、心脏指数,提升乳酸清除率、尿量,改善患者短期预后,且安全性可靠。 |
| 英文摘要: |
| Objective: To explore the effects of early extracorporeal cardiopulmonary resuscitation (ECPR) combined with intra-aortic balloon pump (IABP) on the return of spontaneous circulation and prognosis in out-of-hospital cardiac arrest patients, aiming to provide a reference for clinical treatment of such patients. Methods A prospective study was conducted, including 118 out-of-hospital cardiac arrest patients admitted to Anyang People"s Hospital fromFrom January 2025 to March 2026. Patients were randomly divided into an observation group (n=59) and a control group (n=59) using a random number table. The control group received ECPR treatment, while the observation group received early IABP treatment (within 60 minutes after ECPR) in addition to ECPR. The two groups were compared regarding mean arterial pressure, cardiac output, cardiac index, the return of spontaneous circulation, lactate clearance rate, urine output, prognosis, and complications. Results Three days after resuscitation, mean arterial pressure increased in both groups (P<0.05).At 4 hours and 3 days post-resuscitation, mean arterial pressure in the observation group was higher than in the control group (P<0.05). After treatment, cardiac output and cardiac index increased in both groups (P<0.05), with higher values in the observation group (P<0.05). The return of spontaneous circulation rate in the observation group was higher than in the control group (P<0.05). After treatment, lactate clearance rate and urine output increased in both groups (P<0.05), with higher levels in the observation group (P<0.05). The observation group had higher rates of good neurological prognosis, 24-hour survival, and 30-day survival compared to the control group (P<0.05). No statistical difference was observed in the overall complication rate between the two groups (P>0.05). Conclusion Combining ECPR with IABP early can improve the return of spontaneous circulation in out-of-hospital cardiac arrest patients, boost mean arterial pressure, cardiac output, and cardiac index, increase lactate clearance and urine output, improve short-term outcomes, and is safe and reliable. |
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