| 刘俊潇,杨海澜.肠道菌群及其代谢物在子痫前期发病和治疗中的研究进展[J].安徽医药,2026,30(7):1309-1313. |
| 肠道菌群及其代谢物在子痫前期发病和治疗中的研究进展 |
| Advances in the study of intestinal microbiota and its metabolites in the pathogenesis and treatment of preeclampsia |
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| DOI：10.3969/j.issn.1009-6469.2026.07.007 |
| 中文关键词: 子痫前期 肠道菌群 肠道菌群代谢物 炎症 治疗 |
| 英文关键词: Preeclampsia Intestinal microbiota Intestinal microbiota metabolites Inflammation Treatment |
| 基金项目:中央引导地方科技发展资金项目( YDZJSX2022B010) |
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| 中文摘要: |
| 子痫前期( preeclampsia，PE)是妊娠期特有的并发症，以 20周以后新发高血压和蛋白尿为特征，表现为全身性小血管痉挛。子痫前期致病的机制具有多因素、多机制及多通路的特点，因此至今尚未完全明确。近年研究发现，肠道菌群在妊娠期间发生重大变化，在 PE的发生发展中发挥重要作用，其代谢产物也作为菌群和宿主之间的重要联系参与 PE发生发展。通过探讨肠道微生物群影响子痫前期发生发展的可能机制，可以为寻找防治 PE的新策略提供理论依据。 |
| 英文摘要: |
| Preeclampsia (PE) is a unique complication of pregnancy, characterized by new-onset hypertension and proteinuria after 20weeks of gestation, and manifested by systemic small vessel spasm. The pathogenic mechanism of PE is characterized by multi-factors, multi-mechanisms and multi-pathways, so it has not been completely clarified so far. Recent studies have found that the gut microbiotaundergoes significant changes during pregnancy and plays an important role in the development of PE, and its metabolites also partici-pate in the development of PE as an important link between the microbiota and the host. By exploring the possible mechanisms bywhich the gut microbiota influences the development of PE, it can provide a theoretical basis for finding new strategies to prevent andcontrol PE. |
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