| 唐梅,刘燕,熊宇星,等.不同化疗方案对乳腺癌病人卵巢功能影响的研究进展[J].安徽医药,2026,30(7):1313-1316. |
| 不同化疗方案对乳腺癌病人卵巢功能影响的研究进展 |
| Research progress on the effect of different chemotherapy regimens on ovarian function in patients with breast cancer |
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| DOI：10.3969/j.issn.1009-6469.2026.07.008 |
| 中文关键词: 乳腺肿瘤 抗肿瘤联合化疗方案 卵巢功能 闭经 生育力保护 |
| 英文关键词: Breast neoplasms Antineoplastic combined chemotherapy protocols Ovarial function Amenorrhea Fertility pres-ervation |
| 基金项目:中国金属学会冶金安全与健康分会健康卫生科研项目( jkws202351) |
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| 中文摘要: |
| 乳腺癌是中国女性最常见的恶性肿瘤，随着肿瘤病人年轻化、女性生育年龄延迟，以及辅助生殖技术的普及，乳腺癌病人的生育力保护问题日益受到关注。目前联合化疗应用广泛，乳腺癌病人卵巢受损害的程度与化疗药物种类、剂量、病人年龄及个体差异有关，不同化疗方案对卵巢功能的损害程度各不相同。由于乳腺癌化疗方案的复杂性，尚缺乏有效的研究来评估不同化疗方案的卵巢毒性。所以在诊断和治疗疾病的过程中，应该根据病人的具体情况，选择合适的化疗方案，最大限度地减少对卵巢功能的损害。该研究旨在评估化疗对乳腺癌病人卵巢功能的影响，以在治疗后最大限度地保留病人生育功能。 |
| 英文摘要: |
| Breast cancer is a highly prevalent malignant tumor among women. The younger age of cancer patients, delayed childbear-ing, and increased use of assisted reproduction technology have brought significant attention to fertility preservation for breast cancerpatients. Currently, combined chemotherapy is commonly used, and the extent of ovarian damage in patients varies depending on indi-vidual differences, age, and the type and dose of chemotherapy drugs administered. Different chemotherapy regimens have different ef-fects on ovarian function. However, the complexity of breast cancer chemotherapy regimens has led to a lack of effective research on as-sessing ovarian toxicity. Hence, selecting suitable treatment alternatives according to the patient's particular circumstances is of utmostimportance in order to minimize the adverse effects on ovarian function throughout the course of disease diagnosis and therapy. This re-view aims to evaluate the influence of chemotherapy on ovarian function in individuals diagnosed with breast cancer, with the primarygoal of preserving reproductive capacity to the greatest extent possible after treatment. |
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