| 梁育儒,张昊飞,高京.烧伤感染病人血清 FMS样酪氨酸激酶 3配体、基质细胞衍生因子 -1水平及其诊断价值[J].安徽医药,2026,30(7):1359-1363. |
| 烧伤感染病人血清 FMS样酪氨酸激酶 3配体、基质细胞衍生因子 -1水平及其诊断价值 |
| Levels and diagnostic value of serum FMS-like tyrosine kinase 3 ligand and stromal cell-derived factor-1 in patients with burn wound infection |
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| DOI：10.3969/j.issn.1009-6469.2026.07.017 |
| 中文关键词: 烧伤 感染 FMS样酪氨酸激酶 3配体 基质细胞衍生因子 -1 诊断价值 |
| 英文关键词: Burns Infection FMS-like tyrosine kinase 3 ligand Stromal cell-derived factor-1 Diagnostic value |
| 基金项目:河北省医学科学研究项目( 20220473) |
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| 中文摘要: |
| 目的探究烧伤感染病人血清 FMS样酪氨酸激酶 3配体(Flt3L)、基质细胞衍生因子 -1(SDF-1)水平及其诊断价值。方法该研究为前瞻性研究。选取 2022年4月至 2023年 8月邯郸邯钢医院治疗的 119例烧伤病人为观察组，根据病人感染情况分为脓毒症组(22例)局部感染组(34例)和未感染组(63例)另选取 119例同期在该院体检的健康者为健康组。比较各组血清 Flt3L、SDF-1的水平；logistic、回归分析探究烧伤病人感染的影响因素，；受试者操作特征曲线(ROC曲线)分析血清 Flt3L、SDF-1水平对烧伤病人感染的诊断价值。结果与健康组相比，观察组血清 Flt3L［(134.68±17.65)ng/L比(753.40±79.79)ng/L］、SDF-1［(154.78±25.76)ng/L比(242.34±31.64)ng/L］水平明显升高(P<0.01)；与未感染组相比，脓毒症组和局部感染组病人烧伤至入院时间、烧伤程度为重度占比均明显升高(P<0.01)且与局部感染组相比，脓毒症组病人烧伤至入院时间、烧伤程度为重度占比明显升高(P<0.05)；随感染程度加重，血清 Flt3L、SDF-1水，平依次升高(P<0.05)；烧伤至入院时间、烧伤程度及 Flt3L、SDF-1为烧伤病人感染的独立危险因素(P<0.05)；血清 Flt3L、SDF-1水平诊断烧伤病人感染的曲线下面积(AUC)分别为 0.818、0.821，截断值分别为 768.30 ng/L、244.82 ng/L，二者联合诊断的 AUC为0.910，二者联合优于各自单独诊断(Z二者联合 -Flt3L=1.99、Z二者联合 -SDF-1=2.10，P=0.046、0.036)。结论烧伤感染病人血清 Flt3L、SDF-1水平上调，且均为烧伤病人感染的独立危险因素，二者联合对烧伤感染具有较高的诊断价值。 |
| 英文摘要: |
| Objective To investigate the serum levels of FMS-like tyrosine kinase 3 ligand (Flt3L) and stromal cell-derived factor-1 (SDF-1) in patients with burn wound infection and their diagnostic value.Methods The study is a prospective research. A total of 119burn patients treated in Handan Hangang Hospital from April 2022 to August 2023 were regarded as the observation group. Accordingto the infection status of the patients, they were divided into a sepsis group (n=22), a local infection group (n=34), and a non-infected group (n=63). An additional 119 healthy individuals who underwent physical examination in the same hospital were regarded as thecontrol group. The levels of serum Flt3L and SDF-1 were compared among the groups. Logistic regression analysis was ,made to identifythe influencing factors for infection in burn patients. The diagnostic value of serum Flt3L and SDF-1 levels for infection in burn pa-tients was analyzed using the receiver operating characteristic curve (ROC curve).Results Compared with the control group, the se-rum levels of Flt3L [(134.68±17.65) ng/L vs. (753.40±79.79) ng/L] and SDF-1 [(154.78±25.76) ng/L vs. (242.34±31.64) ng/L] in the ob-servation group were significantly higher (P<0.01). Compared with the non-infected group, the time from burn injury to hospital admis-sion and the proportion of severe burns were significantly in the sepsis group and the local infection group (P<0.01), and compared withthe local infection group, the time from burn injury to hospital admission and the proportion of severe burns were significantly higher inthe sepsis group (P<0.05). The levels of serum Flt3L and SDF-1 increased progressively with the severity of infection (P<0.05). Time from burn injury to hospital admission, burn severity, Flt3L and SDF-1 were independent risk factors for infection in burn patients (P< 0.05) The area under the curve (AUC) for serum Flt3L and SDF-1 levels in diagnosing infection in burn patients was 0.818 and 0.821, respectively, with corresponding cut-off values of 768.30 ng/L and 244.82 ng/L. The AUC for the combination of the two markers was0.910, which was superior to either marker alone (Zcombination-Flt3L=1.99, Zcombination-SDF-1=2.10, P=0.046, 0.036).Conclusions The serum lev-els of Flt3L and SDF-1 are up-regulated in burn patients with infection, and both are independent risk factors for burn wound infection.The combination of the two markers has high diagnostic value for burn wound infection. |
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