| 梁同静,夏立君,冯晓娜,等.健脾祛风止痒汤联合依巴斯汀对急性荨麻疹病人中医症候积分及淋巴毒素水平的影响[J].安徽医药,2026,30(7):1457-1461. |
| 健脾祛风止痒汤联合依巴斯汀对急性荨麻疹病人中医症候积分及淋巴毒素水平的影响 |
| Effect of Jianpi Qufeng Zhiyang decoction combined with ebastine on Traditional Chinese Medicine syndrome scores and lymphotoxin level in patients with acute urticaria |
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| DOI：10.3969/j.issn.1009-6469.2026.07.036 |
| 中文关键词: 荨麻疹 依巴斯汀 健脾祛风止痒汤 实验室指标 中医证候 |
| 英文关键词: Urticaria Ebastine Jianpi Qufeng Zhiyang decoction Laboratory indicators Traditongal Chinese Medicine syn-drome |
| 基金项目:河北省中医药管理局资助项目( 2024506) |
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| 中文摘要: |
| 目的探讨健脾祛风止痒汤 +依巴斯汀对急性荨麻疹( AU)治疗的效果。方法前瞻性选择 2022年 10月至 2023年 10月于衡水市中医医院治疗的 AU病人 120例以随机数字表法分为西药组、联合组，各 60例。西药组采用依巴斯汀治疗，联合组加用健脾祛风止痒汤。比较两组总有效率、中医证候、实验室指标、生化指标、生活质量及不良反应。结果联合组总有效率( 90.00%)显著高于西药组( 73.33%)(P<0.05)中医证候积分显著低于西药组( P<0.05)；联合组白细胞计数、白细胞介素 -4(IL-4)、嗜酸性粒细胞计数( EOS)、白三烯、总免，疫球蛋白 E(tIgE)水平显著低于西药组( P<0.05)，γ干扰素( IFN-γ)水平显著高于西药组( P<0.05)；联合组皮肤病生活质量指数量表( DLQI)评分显著低于西药组，总不良反应率显著降低( P<0.05)。结论 AU病人接受上述联合方案治疗，可有效抑制疾病进展，改善病人临床症状，效果较为理想，有一定应用价值。 |
| 英文摘要: |
| Objective To explore the therapeutic effect of Jianpi Qufeng Zhiyang decoction+ebastine on acute urticaria (AU).Meth. ods Prospective selection one hundred and twenty AU patients who were treated in Hengshui City Traditongal Chinese MedicineHospital from October 2022 to October 2023 were randomly separated into a Western Medicine group and a combination group, with60 cases in each group. The Western Medicine group was treated with ebastine, while the combined group was treated with Jianpi Qufeng Zhiyang decoction. The total effective rate, Traditional Chinese Medicine syndrome, laboratory indicators, biochemical indica-tors, quality of life, and adverse reactions were compared between the two groups.Results The total effective rate of the combination group (90.00%) was obviously higher than that of the Western Medicine group (73.33%) (P<0.05), and the TCM syndrome score was obviously lower than that of the Western Medicine group (P<0.05). The levels of white blood cell count (WBC), interleukin-4 (IL-4), eo-sinophil count (EOS), leukotriene (LT), and total immunoglobulin E (tIgE) in the combination group were obviously lower than those inthe Western Medicine group (P<0.05), while the level of interferon-γ (IFN-γ) was obviously higher than that in the Western Medicine group (P<0.05). The dermatology life quality index (DLQI) score of the combined group was obviously lower than that of the WesternMedicine group, and the incidence of adverse reactions was obviously reduced (P<0.05).Conclusion The combination therapy men-tioned above can effectively inhibit disease progression and improve clinical symptoms in AU patients, with ideal results and certainapplication value. |
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