| 王佳,李朝君,李雅忠.解郁断酒方联合奥沙西泮治疗酒精戒断综合征的随机对照试验[J].安徽医药,2026,30(7):1461-1466. |
| 解郁断酒方联合奥沙西泮治疗酒精戒断综合征的随机对照试验 |
| Randomized controlled study on the treatment of alcohol withdrawal syndrome with Jieyu Duanjiu formula combined with oxazepam |
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| DOI：10.3969/j.issn.1009-6469.2026.07.037 |
| 中文关键词: 酒精依赖 解郁断酒方 奥沙西泮 肠道菌群 神经递质 炎症反应 |
| 英文关键词: Alcohol dependence Jieyu Duanjiu formula Oxazepam Intestinal flora Neurotransmitter Inflammatory reaction |
| 基金项目:河北省中医药类科学研究课题计划项目( 2024157) |
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| 中文摘要: |
| 目的探讨解郁断酒方联合奥沙西泮治疗酒精戒断综合征的疗效。方法选取 2022年 2月至 2024年 2月唐山市第五医院接收的 92例酒精戒断综合征病人，采用随机数字表法分为两组，各 46例。对照组予以奥沙西泮治疗，观察组予以解郁断酒方 +奥沙西泮治疗，均治疗 6周。比较两组治疗后疗效、治疗前后病情相关评分［汉密尔顿焦虑量表( HAMA)、宾夕法尼亚酒精渴求量表( PACS)、汉密尔顿抑郁量表( HAMD)、酒精戒断状态评定量表( AWS)］、炎症相关指标［中性粒细胞与淋巴细胞比值( NLR)、单核细胞与淋巴细胞比值( MLR)］、肠道菌群情况(肠球菌、大肠杆菌、乳酸杆菌、双歧杆菌)、血清神经递质［摄食素(Orexin)、去甲肾上腺素( NE)、 5-羟色胺( 5-HT)、多巴胺( DA)］及不良反应。结果观察组治疗总有效率(95.65%)高于对照组(80.43%)(P<0.05)；治疗后观察组 HAMA、HAMD、AWS、PACS评分低于对照组( P<0.05)；治疗后观察组肠球菌、大肠杆菌含量少于对照组，乳酸杆菌、双歧杆菌含量多于对照组，血清 NE、5-HT、Orexin、NLR、MLR水平低于对照组，多巴胺水平高于对照组(P<0.05)；两组不良反应总发生率比较，差异统计学意义( P>0.05)。结论解郁断酒方联合奥沙西泮治疗酒精戒断综合征效果显著，可有效调节神经递质，抑制炎症反应，改善肠道菌群，减少病人对酒精渴望度，改善戒断状态及焦虑抑郁情绪。 |
| 英文摘要: |
| Objective To explore the efficacy of Jieyu Duanjiu formula combined with Oxazepam in the treatment of alcohol with-drawal syndrome.Methods A total of 92 patients with alcohol withdrawal syndrome admitted to the Department of Psychiatry, Tang-shan Fifth Hospital from February 2022 to February 2024 were selected, and divided into two groups by the random number table meth-od, with 46 patients in each group. The control group was treated with oxazepam, while the observation group was treated with Jieyu Duanjiu formula + oxazepam, with a treatment course of 6 weeks in both groups. The clinical efficacy after treatment, as well as the dis-ease-related scores [Hamilton anxiety scale (HAMA), Penn alcohol craving scale (PACS), Hamilton depression scale (HAMD), Alcohol withdrawal scale (AWS)], inflammation-related indicators [Neutrophils-to-lymphocytes ratio (NLR), Monocytes-to-lymphocyte ratio(MLR)], intestinal flora conditions (Enterococcus, Escherichia coli, Lactobacillus, Bifidobacterium), serum neurotransmitters [Orexin,Norepinephrine (NE), 5-Hydroxytryptamine (5-HT), Dopamine (DA)] before and after treatment, and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group (95.65%) was higher than that in the con-trol group (80.43%) (P<0.05). After treatment, the scores of HAMA, HAMD, AWS, and PACS in the observation group were lower thanthose in the control group (P<0.05). After treatment, the observation group had lower levels of Enterococcus and Escherichia coli thanthe control group, while the levels of Lactobacillus and Bifidobacterium were higher. The levels of serum NE, 5-HT, Orexin, NLR, andMLR were lower in the observation group than those in the control group, while the dopamine level was higher (P<0.05). There was a statistically significant difference in the overall incidence of adverse reactions between the two groups (P>0.05). Conclusion The treatment of alcohol withdrawal syndrome with the combination of Jieyu Duanjiu formula and Oxazepam has significant effects, whichcan effectively regulate neurotransmitters, inhibit inflammatory reactions, improve intestinal flora, reduce patients' cravings for alcohol,and improve withdrawal symptoms and anxiety and depression. |
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