| 杜鑫,赵桐,吕树刚,等.长链非编码 RNA小核仁 RNA宿主基因在骨科相关疾病中的研究进展[J].安徽医药,2026,30(8):1485-1491. |
| 长链非编码 RNA小核仁 RNA宿主基因在骨科相关疾病中的研究进展 |
| Research progress of lncRNA SNHGs in orthopedic-related diseases |
| |
| DOI：10.3969/j.issn.1009-6469.2026.08.001 |
| 中文关键词: RNA，长链非编码 核仁 RNA 小核仁 RNA宿主基因 非编码 RNA 分子机制 骨肉瘤 骨关节炎 |
| 英文关键词: RNA, long noncoding Nucleolar RNA lncRNA SNHGs Non-coding RNA Molecular mechanism Osteosarco-ma Osteoarthritis |
| 基金项目:甘肃省自然科学基金项目( 22JR11RA039) |
|
| 摘要点击次数: 225 |
| 全文下载次数: 30 |
| 中文摘要: |
| 近年来，随着分子生物学研究的深入，长链非编码 RNA(lncRNA)在骨科疾病中的作用逐渐受到关注。其中， lncRNA小核仁 RNA宿主基因( SNHGs)家族作为 lncRNA的重要成员，在骨科疾病中展现出独特的调控机制。研究表明， lncRNA SNHGs通过参与表观遗传调控、转录调控及转录后调控等途径，影响细胞的增殖、分化及凋亡过程，从而在骨肉瘤、骨关节炎、骨质疏松、脊髓损伤、骨折愈合等多种骨科疾病的发生发展中发挥重要作用。 |
| 英文摘要: |
| In recent years, with the advances in molecular biology research, the role of long non-coding RNA (lncRNA) in orthopaedicdiseases has gradually received attention. Among them, the lncRNA small nucleolar RNA host genes (SNHGs) family, as an importantmember of lncRNAs, has shown a unique regulatory mechanism in orthopaedic diseases. Studies have shown that lncRNA SNHGs af-fect the process of cell proliferation, differentiation and apoptosis by participating in epigenetic regulation, transcriptional regulation,and post-transcriptional regulation, thus playing a crucial part in the development of various orthopaedic diseases, such as osteosarco-ma, osteoarthritis, osteoporosis, spinal cord injury, and bone fracture healing. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
