| 高静,乔光莉,俞大鸿,等.宫颈人乳头瘤病毒持续感染药物治疗进展[J].安徽医药,2026,30(8):1497-1502. |
| 宫颈人乳头瘤病毒持续感染药物治疗进展 |
| The progress of medical treatment for continuous infection of cervical human papillomavirus |
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| DOI：10.3969/j.issn.1009-6469.2026.08.003 |
| 中文关键词: 病毒性疾病 人乳头瘤病毒(HPV) 宫颈鳞状上皮内病变 抗病毒药 |
| 英文关键词: Viral diseases Human papilloma virus (HPV) Squamous intraepithelial lesions of the cervix Antiviral agents |
| 基金项目:宁夏回族自治区科技惠民项目( 2022KJHM0087) |
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| 中文摘要: |
| 宫颈癌的发病原因主要与高危型人乳头瘤病毒(HPV)的持续感染密切相关，宫颈低级别鳞状上皮内病变( LSIL)以药物治疗及随访观察为主，宫颈高级别鳞状上皮内病变( HSIL)以宫颈锥切术或结合药物治疗为主，但手术仅能切除病变组织，不能清除 HPV感染，术后病毒持续感染可导致病变复发甚至进展，积极根除高危 HPV持续感染对于疾病转归和预后意义重大。目前临床上无针对 HPV感染的特效药物，该研究通过文献回顾近几年临床上使用的抗 HPV药物的治疗进展及疗效对比，为临床药物治疗的个体化选择提供参考。 |
| 英文摘要: |
| The pathogenesis of cervical cancer is mainly associated with the persistent infection of high-risk human papillomavirus (HPV). Low-grade squamous intraepithelial lesions (LSIL) of the cervix are mainly managed with medication and follow-up observation, whereas high-grade squamous intraepithelial lesions (HSIL) are primarily treated with cervical conization, sometimes combined withpharmacotherapy. However, surgery can only remove the diseased tissue but cannot clear the HPV infection, and persistent postopera-tive viral infection may lead to the recurrence or even progression of the disease. Therefore, actively eradicating persistent high-risk HPV infection is of great significance for disease outcome and prognosis. Currently, there is no specific drug for HPV infection in clini-cal practice. This study reviews the therapeutic mechanism and efficacy of anti-HPV drugs used in clinical practice in recent yearsthrough a literature review, aiming to provide a reference for individualized selection of clinical drug therapy. |
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