| 李铖,张婷,屈重霄.核纤层蛋白 B1的功能及其在肿瘤诊疗及预后中潜在价值的研究新进展[J].安徽医药,2026,30(8):1515-1520. |
| 核纤层蛋白 B1的功能及其在肿瘤诊疗及预后中潜在价值的研究新进展 |
| New advances in the study of the function of nuclear fibrillar layer protein B1 and its potential value in the diagnosis and prognosis of tumours |
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| DOI：10.3969/j.issn.1009-6469.2026.08.006 |
| 中文关键词: 核纤层蛋白 B型 核纤层蛋白 B1基因 肿瘤 肺腺癌 前列腺癌 |
| 英文关键词: Lamin type B LMNB1 Tumour Lung adenocarcinoma Prostatic cancer |
| 基金项目:山西省基础研究计划项目( 202303021211053) |
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| 中文摘要: |
| B型核纤层蛋白是核层的基本组成部分，参与调节 DNA复制和修复、染色质结构以及核膜的稳定性，并且在调控多种细胞生理过程中发挥重要作用，如组织发育、细胞周期、细胞增殖、衰老和 DNA损伤反应，在胚胎发育过程中，它对器官的形成，尤其是大脑的发育至关重要。其表达异常与多种疾病有关，如神经系统疾病及肿瘤等，是潜在的药物靶点和肿瘤标志物。 |
| 英文摘要: |
| B-type lamins are essential components of the nuclear lamina and are involved in the regulation of DNA replication and re-pair, chromatin structure, and the stability of the nuclear membrane. They also play an important role in regulating a variety of cellphysiological processes, such as tissue development, cell cycle, cell proliferation, senescence, and the DNA damage response. Duringembryonic development, they are critical for organ formation, particularly for brain development. Aberrant expression of B-type laminsis associated with a variety of diseases, including neurological disorders and tumours, which serves as a potential drug target and tu-mour marker. |
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