| 钟锐,周坤元,彭华.Shh信号通路在脑梗死治疗中的研究进展[J].安徽医药,2026,30(8):1532-1535. |
| Shh信号通路在脑梗死治疗中的研究进展 |
| Research progress of Shh signaling pathway in the treatment of cerebral infarction |
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| DOI：10.3969/j.issn.1009-6469.2026.08.009 |
| 中文关键词: 脑梗死 音猬因子(Shh) 血管再生 神经元重塑 研究进展 |
| 英文关键词: Cerebral infarction Sonic hedgehog(Shh) Angiogenesis Neuronal remodeling Research progress |
| 基金项目:梅州市科技计划项目( 2018B021) |
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| 摘要点击次数: 178 |
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| 中文摘要: |
| 脑梗死是常见脑部疾病，老龄化加剧其发生，且青年人发病增多，致残率高、生存质量差。其发病机制复杂，音猬因子 |
| 英文摘要: |
| Cerebral infarction is a common brain disorder. Aging aggravates its occurrence, and the incidence among young people isincreasing, with high disability rate and poor quality of life. Its pathogenesis is complex, and the sonic hedgehog (Shh) signaling path-way is involved abnormally. This pathway consists of Shh ligands, Ptc, Smo receptors, and Gli transcription factors, which regulate cellproliferation, differentiation, and migration under normal physiological conditions. In the pathological state of cerebral infarction, it canplay a role by promoting angiogenesis, promoting nerve regeneration, enhancing neuronal plasticity, and inhibiting neuronal apoptosis,providing new targets and strategies for the treatment of cerebral infarction. |
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