| 海中烨,刘宏生,孙梓灵,等.骨肉瘤病人焦虑抑郁潜在类别分析及与生存质量的关系探讨[J].安徽医药,2026,30(8):1567-1571. |
| 骨肉瘤病人焦虑抑郁潜在类别分析及与生存质量的关系探讨 |
| Latent class analysis of anxiety and depression in patients with osteosarcoma and their relationship with quality of life |
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| DOI：10.3969/j.issn.1009-6469.2026.08.016 |
| 中文关键词: 骨肉瘤 焦虑 抑郁 潜在类别分析 生存质量 |
| 英文关键词: Osteosarcoma Anxiety Depression Latent class analysis Quality of life |
| 基金项目:河南省医学科技攻关计划项目( SBGJ202302053) |
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| 中文摘要: |
| 目的探讨骨肉瘤病人焦虑抑郁潜在类别，并分析其与生存质量的关系。方法前瞻性选取 2022年 1月至 2023年 10月郑州大学第一附属医院收治的 113例骨肉瘤病人，采用医院焦虑抑郁量表( HADS)评估病人的焦虑抑郁情况，并进行潜在类别分析建立亚组。应用生命质量测定量表( QLQ-C30)评估骨肉瘤病人的生存质量，比较不同焦虑抑郁情况骨肉瘤病人的生存质量；通过多元线性回归方程探究骨肉瘤病人生存质量的影响因素。结果骨肉瘤病人焦虑抑郁 3个潜在类别的模型拟合效果最优，概率分别为 26.2%、29.8%和 44.0%，分别命名为焦虑型、抑郁型和焦虑抑郁型；治疗过程中有 2例病人转院， 111例骨肉瘤病人生存质量得分为( 72.95±12.18)分，其中焦虑型、抑郁型、焦虑抑郁型病人生存质量得分分别为( 79.38±14.02)分、(77.97±13.84)分、(65.76±11.24)分，焦虑型和抑郁型病人生存质量得分差异无统计学意义( P>0.05)焦虑抑郁型病人生存质量得分低于焦虑型和抑郁型( P<0.05)；多元线性回归分析结果显示， Enneking分期 Ⅲ期、分化程度未，/低分化、截肢手术、焦虑抑郁型均是骨肉瘤病人生存质量的影响因素( P<0.05)。结论骨肉瘤病人焦虑抑郁存在焦虑型、抑郁型和焦虑抑郁型 3种潜在类别，且 Enneking分期、分化程度、手术类型以及焦虑抑郁潜在类别与生存质量相关。 |
| 英文摘要: |
| Objective To explore the latent classes of anxiety and depression in patients with osteosarcoma, and to analyze their rela-tionship with quality of life.Methods Prospective selection of 113 patients with osteosarcoma admitted to The First Affiliated Hospitalof Zhengzhou University from January 2022 to October 2023 were selected to assess the anxiety and depression status of the patients us-ing the hospital anxiety and depression scale (HADS), and the latent class analysis was conducted to establish subgroups. Quality of lifequestionnaire (QLQ-C30) was used to evaluate the quality of life in osteosarcoma patients and compare the quality of life in osteosarco-ma patients with different anxiety and depression profiles. The factors influencing the quality of life in patients with osteosarcoma wereinvestigated by multiple linear regression equation.Results The model fitting effect of three latent classes of anxiety and depression inosteosarcoma patients was the best, with the probabilities of 26.2%, 29.8% and 44.0%, respectively, which were named as anxiety type,depression type and anxiety-depression type. During the treatment, two patients were transferred to another hospital, the quality of lifescore for 111 patients with osteosarcoma was (72.95 ± 12.18) points. The quality of life scores for patients with anxiety type, depressiontype and anxiety-depression type were (79.38 ± 14.02) points, (77.97 ± 13.84) points, and (65.76 ± 11.24) points, respectively, andthere was no significant difference in the quality of life scores between patients with anxiety type and those with depression type (P > 0.05), and the quality of life score of patients with anxiety-depression type was lower than that of patients with anxiety type and depres-sion type (P<0.05). The results of multiple linear regression analysis showed that Enneking stage Ⅲ, undifferentiated/poorly differenti-ated degree of differentiation, amputation surgery, and anxiety-depression type were all influencing factors for the quality of life in pa-tients with osteosarcoma (P<0.05).Conclusions There are three latent classes of anxiety and depression in osteosarcoma patients: anx-iety type, depression type and anxiety-depression type. Enneking stage, degree of differentiation, surgery type and latent classes of anxi-ety and depression are correlated with quality of life. |
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