| 高辉,付玉平,许殿勇.基于MRI探究膝骨关节炎患者交叉韧带周围脂肪垫变化及其与严重程度的关系[J].安徽医药,待发表. |
| 基于MRI探究膝骨关节炎患者交叉韧带周围脂肪垫变化及其与严重程度的关系 |
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| 投稿时间：2026-08-21 录用日期：2026-10-27 |
| DOI： |
| 中文关键词: 膝骨关节炎 交叉韧带周围脂肪垫 磁共振成像 严重程度 |
| 英文关键词: |
| 基金项目: |
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| 中文摘要: |
| 目的 基于磁共振成像（MRI）探究膝骨关节炎（KOA）患者交叉韧带周围脂肪垫变化及其与严重程度的关系。方法 选取医院2022年1月至2025年3月100例疑似KOA患者，均行MRI、关节镜检查。根据关节镜检查结果分为KOA组及非KOA组，比较两组交叉韧带周围脂肪垫MRI参数[交叉韧带周围脂肪垫脂肪分数（FF）值、交叉韧带周围脂肪垫T2值、交叉韧带周围脂肪垫最大横截面积]，以受试者工作特征（ROC）曲线分析交叉韧带周围脂肪垫MRI参数对KOA的诊断价值。比较不同严重程度KOA患者交叉韧带周围脂肪垫MRI参数及膝功能损伤程度，以Spearman相关性分析KOA患者交叉韧带周围脂肪垫MRI参数与病情严重程度的关系。结果 KOA组交叉韧带周围脂肪垫FF值、交叉韧带周围脂肪垫T2值、交叉韧带周围脂肪垫最大横截面积均高于非KOA组（P＜0.05）；ROC曲线显示，交叉韧带周围脂肪垫FF值、交叉韧带周围脂肪垫T2值、交叉韧带周围脂肪垫最大横截面积联合诊断KOA的曲线下面积（AUC）为0.933，高于三者单独诊断的0.786、0.817、0.796（P＜0.05）；重度组交叉韧带周围脂肪垫FF值、交叉韧带周围脂肪垫T2值、交叉韧带周围脂肪垫最大横截面积均高于中度组、轻度组，美国膝关节协会评分（KSS）低于中度组、轻度组（P＜0.05）；中度组交叉韧带周围脂肪垫FF值、交叉韧带周围脂肪垫T2值、交叉韧带周围脂肪垫最大横截面积均高于轻度组，KSS低于轻度组（P＜0.05）；Spearman相关性分析显示，KOA患者交叉韧带周围脂肪垫FF值、交叉韧带周围脂肪垫T2值、交叉韧带周围脂肪垫最大横截面积均与Kellgren-Lawrence分级呈正相关，与KSS呈负相关（P＜0.05）。结论 KOA患者交叉韧带周围脂肪垫MRI信号变化能辅助诊断KOA，且与严重程度存在相关性。 |
| 英文摘要: |
| Objective To explore the changes of pericruciate fat pad (PCFP) and their relationship with disease severity in patients with knee osteoarthritis (KOA) based on magnetic resonance imaging (MRI). Methods A total of 100 patients with suspected KOA in the hospital were enrolled between January 2022 and March 2025, and all underwent MRI examination and arthroscopy. According to arthroscopy results, they were divided into KOA group and non-KOA group. MRI parameters of PCFP [fat fraction (FF), T2 value, the maximum cross-sectional area] were compared between the two groups. The diagnostic value of PCFP parameters in KOA was analyzed by receiver operating characteristic (ROC) curves. MRI parameters of PCFP and severity of knee function injury in patients with different severity of KOA were compared. The relationship between MRI parameters of PCFP and disease severity in KOA patients was analyzed by Spearman correlation analysis. Results FF, T2 value and the maximum cross-sectional area of PCFP in KOA group were higher than those in non-KOA group (P<0.05). ROC curves analysis showed that area under the curve (AUC) of FF combined with T2 value and the maximum cross-sectional area in the diagnosis of KOA was 0.933, greater than that of single index (0.786, 0.817, 0.796; P<0.05). In mild group, moderate group and severe group, FF, T2 value and the maximum cross-sectional area of PCFP were gradually increased, while knee society score (KSS) was gradually decreased (P<0.05). Spearman correlation analysis showed that FF, T2 value and the maximum cross-sectional area of PCFP were positively correlated with Kellgren-Lawrence grading, while negatively correlated with KSS (P<0.05). Conclusion The changes of PCFP MRI signals can assist in the diagnosis of KOA and are correlated with disease severity in KOA patients |
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