| 杭扬,丁帅,孙凌云.炎症小体在系统性红斑狼疮中的研究现状与展望[J].安徽医药,2026,30(9):1697-1703. |
| 炎症小体在系统性红斑狼疮中的研究现状与展望 |
| Research progress and future perspectives of inflammasomes in systemic lupus erythematosus |
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| DOI：10.3969/j.issn.1009-6469.2026.09.001 |
| 中文关键词: 红斑狼疮，系统性 固有免疫 炎症小体 炎症反应 发病机制 研究进展 |
| 英文关键词: Lupus erythematosus, systemic Innate immunity progress |
| 基金项目:国家自然科学基金重点项目( 82330055) |
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| 摘要点击次数: 521 |
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| 中文摘要: |
| 系统性红斑狼疮( SLE)是一种病情迁延、累及多系统的自身免疫疾病，发病机制复杂。近年研究表明，炎症小体作为固有免疫防线的重要效应元件，通过发挥促炎及免疫激活作用显著参与了 SLE的发病进程。该研究对炎症小体在 SLE中的异常激活表现、激活诱因及下游作用机制进行总结，综述其在 SLE诊疗中的应用与研究进展，为炎症小体在 SLE中的机制探索和未来相关疗法的研发提供理论参考。 |
| 英文摘要: |
| Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs and systems, with a com.plex pathogenesis. Recent studies have shown that inflammasome, as the major effector in innate immune defense, significantly partici.pate in the pathogenesis of SLE by exerting pro-inflammatory effects and immune overreaction. This review summarizes the aberrant ac.tivation patterns, activation triggers and downstream mechanisms of inflammasomes in SLE, and provides an overview of their applica.tion and research progress in the diagnosis and treatment of SLE, aiming to provide theoretical foundation for mechanistic explorationand the development of future therapeutic strategies associated with inflammasomes in SLE. |
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