| 赵维倩,张晓俊,郝语晨,等.雌激素受体低表达乳腺癌的机制及治疗进展[J].安徽医药,2026,30(9):1709-1714. |
| 雌激素受体低表达乳腺癌的机制及治疗进展 |
| Mechanisms and therapeutic advances in ER-low breast cancer |
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| DOI：10.3969/j.issn.1009-6469.2026.09.003 |
| 中文关键词: 乳腺肿瘤 雌激素受体 雌激素受体低表达 内分泌治疗 预后 |
| 英文关键词: Breast neoplasms Estrogen receptor Low estrogen receptor expression Endocrine therapy Prognosis |
| 基金项目:山西省基础研究计划(自由探索类)项目( 202303021221190) |
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| 摘要点击次数: 352 |
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| 中文摘要: |
| 雌激素受体(ER)低表达( 1%~10%)乳腺癌是一种特殊类型的 ER阳性乳腺癌。与 ER高表达( >10%)乳腺癌相比， ER低表达乳腺癌在病理特征、预后及对内分泌治疗的反应上存在显著差别，与 ER阴性( ER<1%)乳腺癌更为相似。然而，关于这一现象的具体机制尚未达成共识，这引起了越来越多的临床医师和病理学家的关注。该研究将综述 ER低表达乳腺癌的机制、内分泌治疗的适用性及其他潜在治疗方法。 |
| 英文摘要: |
| Breast cancer with low estrogen receptor (ER) expression (1%-10%) is a distinct subtype of ER-positive breast cancer. Com. pared with breast cancer with high ER expression (>10%), ER-low breast cancer shows significant differences in pathological features,prognosis, and response to endocrine therapy and more closely resembles ER-negative breast cancer (ER<1%). However, no consensushas been reached on the specific mechanisms underlying this phenomenon, which has attracted increasing attention from clinicians andpathologists. This review summarizes the mechanisms of ER-low breast cancer, the applicability of endocrine therapy, and other poten. tial treatment options. |
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