| 王浩然.非编码RNA在慢性阻塞性肺疾病的作用及中医药防治研究进展[J].安徽医药,待发表. |
| 非编码RNA在慢性阻塞性肺疾病的作用及中医药防治研究进展 |
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| 投稿时间：2026-09-06 录用日期：2026-10-22 |
| DOI： |
| 中文关键词: 非编码RNA 慢性阻塞性肺疾病 中医药 作用机制 研究进展 |
| 英文关键词: |
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| 中文摘要: |
| 慢性阻塞性肺疾病(COPD)是以持续性气流受限、慢性气道炎症为特征的异质性肺部疾病,为全球第三大死因,疾病负担沉重。当前临床常规治疗疗效有限且存在不良反应,挖掘新型治疗靶点,探索干预策略具有重要临床价值。非编码RNA(ncRNA)在COPD发病机制中发挥着关键调控作用。本文系统梳理了微小RNA(miRNA)、长链非编码RNA(lncRNA)、环状RNA(circRNA)三类ncRNA通过参与气道炎症、氧化应激、细胞凋亡等多种核心环节在COPD病理过程的作用机制,及中药单体(黄芩苷、白藜芦醇等)、中药复方(补肺益肾方、滋金补水膏、益气固表丸等)及中医外治法(电针、神经肌肉电刺激、穴位贴敷)通过调控ncRNA表达改善COPD的研究进展。以期为COPD防治提供新路径与方法。 |
| 英文摘要: |
| Chronic obstructive pulmonary disease (COPD) is a complex lung disorder characterized by persistent airflow obstruction and chronic inflammation of the airways. It ranks as the third leading cause of mortality globally, imposing a substantial disease burden. Conventional clinical treatments currently exhibit limited efficacy and are often accompanied by adverse effects, underscoring the importance of identifying novel therapeutic targets and intervention strategies. Non-coding RNA (ncRNA) have emerged as critical regulators in the pathogenesis of COPD. This article provides a comprehensive review of the mechanisms through which three categories of ncRNA—microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA)—contribute to key pathological processes such as airway inflammation, oxidative stress, and cell apoptosis in COPD. Furthermore, it examines recent advances in the application of |
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