| 何亦虎,郭建平,郭志强.肿瘤相关巨噬细胞在乳腺癌中的研究进展[J].安徽医药,2026,30(9):1736-1742. |
| 肿瘤相关巨噬细胞在乳腺癌中的研究进展 |
| Research progress on tumor-associated macrophages in breast cancer |
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| DOI：10.3969/j.issn.1009-6469.2026.09.008 |
| 中文关键词: 乳腺肿瘤 肿瘤相关巨噬细胞 肿瘤微环境 病理学完全缓解 治疗靶点 |
| 英文关键词: Breast neoplasms Tumor-associated macrophages Tumor microenvironment Pathologic complete response Ther. apeutic target |
| 基金项目:吕梁市科技计划项目( 2024SHFZ28) |
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| 中文摘要: |
| 乳腺癌是世界范围内女性发病率最高的恶性肿瘤之一。肿瘤相关巨噬细胞( TAMs)是肿瘤微环境中最重要的成分，与乳腺癌的发生发展及治疗息息相关。 TAMs具有高度可塑性，在不同因子刺激下可极化为经典激活的 M1型和交替激活的 M2型巨噬细胞。目前研究认为， TAMs通常具有 M2型巨噬细胞表型，在乳腺癌进展的各个方面发挥了重要作用。该研究主要对 |
| 英文摘要: |
| Breast cancer is one of the most common malignancies in women worldwide. Tumor-associated macrophages (TAMs) areamong the most important components of the tumor microenvironment and are associated with the initiation, progression, and treatmentof breast cancer. TAMs are highly plastic and can be polarized into classically activated M1 and alternately activated M2 macrophagesunder the stimulation of various factors. Current research suggests that TAMs typically exhibit an M2-type macrophage phenotype andplay an important role in various aspects of breast cancer progression. This review summarizes the roles of TAMs in breast cancer, fo.cusing on their functions in angiogenesis invasion and metastasis, and their potential as therapeutic targets. |
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