| 张敬波.SIGIRR、NF-κB、Sestrin2水平对髋关节骨折术后感染的预测价值[J].安徽医药,待发表. |
| SIGIRR、NF-κB、Sestrin2水平对髋关节骨折术后感染的预测价值 |
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| 投稿时间：2026-09-08 录用日期：2026-11-04 |
| DOI： |
| 中文关键词: 单免疫球蛋白白细胞介素1受体相关蛋白 核因子κB 应激诱导蛋白2 髋关节骨折 |
| 英文关键词: |
| 基金项目:河北省中医药管理局项目资助(2023348) |
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| 中文摘要: |
| 目的:探究单免疫球蛋白白细胞介素1受体相关蛋白(single ig IL-1 receptor related protein,SIGIRR)、核因子κB(nuclear factor-kappa B,NF-κB)、Sestrin2在髋关节骨折患者血清水平,并分析联合检测对患者术后感染的预测价值。方法:选取2021年9月至2024年9月于邯郸市中医院接受髋关节骨折手术治疗的患者220例,依据术后7天是否发生感染分为感染组40例,未感染组180例。采用酶联免疫吸附法检测血清SIGIRR、NF-κB、Sestrin2水平；采用Logistic回归模型分析患者术后感染的影响因素；采用受试者工作特征(receiveroperator characterist,ROC)曲线分析血清SIGIRR、NF-κB、Sestrin2水平对患者术后感染的预测价值。结果:相较未感染组,感染组患者血清SIGIRR、NF-κB、Sestrin2水平均出现高表达,骨质疏松患者所占比例增加(P<0.05)；Logistic回归分析显示,血清SIGIRR、NF-κB、Sestrin2水平是影响患者术后感染的危险因素(P<0.05)；ROC曲线显示,血清SIGIRR、NF-κB、Sestrin2水平单独及联合预测患者术后感染的AUC分别为0.844、0.781、0.811及0.944,联合预测的AUC值高于单独预测(P<0.05)。结论:髋关节骨折术后感染患者血清SIGIRR、NF-κB、Sestrin2水平升高,三者联合检测对髋关节骨折患者术后感染具有一定预测价值。 |
| 英文摘要: |
| Objective: To investigate the serum single immunoglobulin interleukin-1 receptor related protein (SIGIRR), nuclear factor-kappa B (NF-κB), and Sestrin 2 in hip fractures, and to analyze the predictive value of combined detection for postoperative infection. Methods: Totally 220 patients who underwent surgical treatment for hip fractures in Handan Hospital of Traditional Chinese Medicine from September 2021 to September 2024 were grouped into infected group of 40 cases and uninfected group of 180 cases based on whether infection occurred 7 days after surgery. Enzyme linked immunosorbent assay was used to test serum SIGIRR, NF-κB, and Sestrin2. Logistic regression model was used to explore the influencing factors of postoperative infection. Moreover, receiver operating characteristic (ROC) curve was used to explore the predictive value of serum SIGIRR, NF-κB, and Sestrin2 for postoperative infection. Results: For the uninfected group, the infected group showed high serum SIGIRR, NF-κB, and Sestrin2, and larger proportion of osteoporosis (P<0.05). Logistic regression revealed that serum SIGIRR, NF-κB, and Sestrin2 were risk factors for postoperative infection (P<0.05). ROC curve revealed that the AUC values of serum SIGIRR, NF-κB, and Sestrin2 alone and their combination for predicting postoperative infection were 0.844, 0.781, 0.811, and 0.944, respectively. The AUC value of combined predict was higher than that of single predict (P<0.05). Conclusion: Serum SIGIRR, NF-κB, and Sestrin2 are elevated in hip fractures patients with postoperative infection. The combined detection of the three has certain predictive value for postoperative infection in hip fractures. |
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