| 何丽渊,冯佰山,葛芙蓉,等.三萜类化合物调控肠道菌群/SCFAs/PI3K/Akt信号通路治疗结直肠癌的研究进展[J].安徽医药,待发表. |
| 三萜类化合物调控肠道菌群/SCFAs/PI3K/Akt信号通路治疗结直肠癌的研究进展 |
|
| 投稿时间：2026-09-09 录用日期：2026-10-10 |
| DOI： |
| 中文关键词: 结直肠癌 三萜类化合物 肠道菌群 短链脂肪酸 PI3K/Akt信号通路 |
| 英文关键词: |
| 基金项目:国家自然科学(82460908)；甘肃省省级中医特色优势专科(肛肠科)项目(00211500101)；甘肃省中医药管理局科研课题(GZKZ-2025-36) |
|
| 摘要点击次数: 77 |
| 全文下载次数: 0 |
| 中文摘要: |
| 结直肠癌（CRC）是全球高发的消化系统恶性肿瘤，肠道菌群紊乱导致的短链脂肪酸（SCFAs）分泌减少与磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）信号通路的持续激活在CRC发生发展中起重要作用。SCFAs可通过激活G蛋白偶联受体43（GPR43）和抑制组蛋白去乙酰化酶（HDAC）调控PI3K/Akt通路。部分三萜类化合物口服后可发生肠道代谢，具有调节肠道菌群、提升SCFAs水平的潜力。本文梳理了肠道菌群/SCFAs/PI3K/Akt信号通路在CRC中的作用机制及三萜类化合物经该途径干预CRC的研究进展。现有研究表明，部分五环三萜和四环三萜可不同程度地富集产丁酸菌、提高SCFAs水平并影响PI3K/Akt通路，但研究多停留于相关性观察，SCFAs的中介作用及直接效应与菌群介导效应的区分尚缺乏直接证据。未来需加强因果验证和临床转化研究，以阐明三萜类化合物经肠道菌群/SCFAs/PI3K/Akt信号通路抗CRC的机制，为三萜类天然药物开发及CRC的中西医结合防治提供理论参考。 |
| 英文摘要: |
| Colorectal cancer (CRC) is a highly prevalent malignant tumor of the digestive system worldwide. The reduction in the secretion of short-chain fatty acids (SCFAs) due to intestinal flora imbalance and the continuous activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway play a significant role in the occurrence and development of CRC. SCFAs can regulate the PI3K/Akt pathway by activating G protein-coupled receptor 43 (GPR43) and inhibiting histone deacetylase (HDAC). Some triterpenoids can undergo intestinal metabolism after oral administration and have the potential to regulate the intestinal flora and increase the level of SCFAs. This article reviews the mechanism of the intestinal flora/SCFAs/PI3K/Akt signaling pathway in CRC and the research progress of triterpenoids intervening in CRC through this pathway. Existing studies have shown that some pentacyclic triterpenoids and tetracyclic triterpenoids can differentially enrich bacteria that produce butyric acid, increase the level of SCFAs, and affect the PI3K/Akt pathway, but most studies have only focused on correlation observations. The mediating role, direct effect of SCFAs, and the distinction from the effect mediated by the flora remain lacking direct evidence. In the future, causal verification and clinical translation studies need to be strengthened to clarify the mechanism of triterpenoids acting against CRC through the intestinal flora/SCFAs/PI3K/Akt signaling pathway, providing theoretical references for the development of triterpenoid natural drugs and the integrated traditional Chinese and Western medicine prevention and treatment of CRC. |
|
查看/发表评论 下载PDF阅读器 |
| 关闭 |
