| 刘婷,高英,哈斯达尔 ·米地里别克,等.血清脂蛋白相关磷脂酶 A2、小而密低密度脂蛋白胆固醇、前蛋白转化酶枯草溶菌素 9、胱抑素 C水平与脂代谢及冠状动脉病变程度的关系研究[J].安徽医药,2026,30(9):1774-1778. |
| 血清脂蛋白相关磷脂酶 A2、小而密低密度脂蛋白胆固醇、前蛋白转化酶枯草溶菌素 9、胱抑素 C水平与脂代谢及冠状动脉病变程度的关系研究 |
| A study on the relationship between levels of serum Lp-PLA2, sdLDL-C, PCSK9, and Cys C with lipid metabolism and degree of coronary artery disease |
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| DOI：10.3969/j.issn.1009-6469.2026.09.014 |
| 中文关键词: 冠心病 脂蛋白相关磷脂酶 A2 小而密低密度脂蛋白胆固醇 前蛋白转化酶枯草溶菌素 9 胱抑素 C 脂代谢 冠状动脉 |
| 英文关键词: Coronary heart disease Lipoprotein associated phospholipase A2 Small and dense low-density lipoprotein cholester. ol Proprotein convertase subtilisin/kexin type 9 Cystatin C Lipid metabolism Coronary artery |
| 基金项目:新疆维吾尔自治区自然科学基金资助项目( 2022D01E23) |
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| 中文摘要: |
| 目的探讨冠心病病人血清中脂蛋白相关磷脂酶 A2(Lp-PLA2)、小而密低密度脂蛋白胆固醇( sdLDL-C)、前蛋白转化酶枯草溶菌素 9(PCSK9)、胱抑素 C(Cys C)水平与脂代谢及冠状动脉(冠脉)病变程度的关系。方法回顾性研究。选取 2020年 8月至 2023年 8月新疆医科大学第一附属医院收治的 361例冠心病作为观察组，另选取 392例同期该院体检健康者为健康组。比较两组血清 Lp-PLA2、sdLDL-C、PCSK9、Cys C水平与脂代谢指标水平，不同冠脉病变程度组血清 Lp-PLA2、sdLDL-C、 PCSK9、Cys C水平与脂代谢指标水平，并采用 Pearson相关性分析检验冠心病病人血清 Lp-PLA2、sdLDL-C、PCSK9、Cys C水平与脂代谢的相关性，采用 Spearman相关性分析检验冠心病病人血清 Lp-PLA2、sdLDL-C、PCSK9、Cys C水平与冠脉病变程度的相关性。结果观察组血清 Lp-PLA2［( 492.32±96.54)U/L比( 261.65±78.54)U/L］、 sdLDL-C［( 1.07±0.24)mmol/L比( 0.25±0.06) mmol/L］、 PCSK9［( 4.76±2.01)μg/L比( 0.96±0.32)μg/L］、 Cys C［( 2.54±0.34)g/L比( 0.68±0.11)g/L］、甘油三酯( TG)、总胆固醇(TC)、低密度脂蛋白胆固醇( LDL-C)水平均高于健康组；观察组血清高密度脂蛋白胆固醇( HDL-C)水平均低于健康组( P<0.05)。重度硬化组血清 Lp-PLA2［(512.87±97.65)U/L比( 487.76±95.43)U/L、(469.65±94.32)U/L］、sdLDL-C［(1.15±0.26)mmol/L比( 1.09±0.26)mmol/L、(1.05±0.24)mmol/L］、 PCSK9［(5.11±2.03)μg/L比( 4.65±1.76)μg/L、(4.32±1.45)μg/L］、 Cys C［(2.65±0.54) g/L比( 2.48±0.49)g/L、(2.01±0.31)g/L］、 TG、TC、LDL-C水平均高于中度硬化组、轻度硬化组，中度硬化组高于轻度硬化组；重度硬化组血清 HDL-C水平均低于中度硬化组、轻度硬化组，中度硬化组低于轻度硬化组( P<0.05)。冠心病病人血清 Lp-PLA2、 sdLDL-C、PCSK9、Cys C水平与 TG、TC、LDL-C均呈正相关，与 HDL-C呈负相关( P<0.05)。冠心病病人血清 Lp-PLA2、sdLDL-C、 PCSK9、Cys C水平与冠脉病变程度均呈正相关( rs=0.56、0.50、0.65、0.71，均 P<0.05)。结论冠心病病人存在脂代谢异常，而 Lp-PLA2、sdLDL-C、PCSK9、Cys C与冠心病的发生及病人脂代谢、冠脉病变程度密切相关，对冠心病病情评估具有重要意义。 |
| 英文摘要: |
| Objective To explore the relationship between levels of serum lipoprotein associated phospholipase A2 (Lp-PLA2), small and dense low-density lipoprotein cholesterol (sdLDL-C), proprotein convertase subtilisin/kexin type 9 (PCSK9), and cystatin C (Cys C)with lipid metabolism and degree of coronary artery disease in patients with coronary heart disease (CHD).Methods A retrospectivestudy was conducted. 361 cases of CHD admitted to The First Affiliated Hospital of Xinjiang Medical University from August 2020 toAugust 2023 were selected as the observation group, and 392 healthy individuals who underwent physical examinations during thesame period were selected as the healthy group. The levels of serum Lp-PLA2, sdLDL-C, PCSK9, Cys C and lipid metabolism indica. tors between two groups, and the levels of serum Lp-PLA2, sdLDL-C, PCSK9, Cys C and lipid metabolism indicators between groupswith different degrees of coronary artery disease were compared. The correlation between levels of serum Lp-PLA2, sdLDL-C, PCSK9,and Cys C and lipid metabolism in patients with CHD were examined by Pearson correlation analysis. And the correlation between lev. els of serum Lp-PLA2, sdLDL-C, PCSK9, and Cys C and the degree of coronary artery disease in patients with CHD were examined by Spearman correlation analysis.Results The levels of serum Lp-PLA2 [(492.32±96.54) U/L vs. (261.65±78.54) U/L], sdLDL-C [(1.07± 0.24) mmol/L vs. (0.25±0.06) mmol/L], PCSK9 [(4.76±2.01) μg/L vs. (0.96±0.32) μg/L], Cys C [(2.54±0.34) mg/L vs. (0.68±0.11) mg/L], triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) in the observation group were higher than those in the healthy group; the levels of serum high-density lipoprotein cholesterol (HDL-C) in the observation group were lower than those in the healthy group (P<0.05). The levels of serum Lp-PLA2 [(512.87±97.65) U/L vs. (487.76±95.43) U/L, (469.65±94.32) U/L], sdLDL-C [(1.15±0.26) mmol/L vs. (1.09±0.26) mmol/L, (1.05±0.24) mmol/L], PCSK9 [(5.11±2.03) μg/L vs. (4.65±1.76) μg/L, (4.32± 1.45) μg/L], Cys C [(2.65±0.54) mg/L vs. (2.48±0.49) mg/L, (2.01±0.31) mg/L], TG, TC, and LDL-C in the severe sclerosis group werehigher than those in the moderate and the mild sclerosis groups, and the moderate sclerosis group was higher than that in the mild scle.rosis group; the levels of serum HDL-C in the severe sclerosis group were lower than those in the moderate and the mild sclerosisgroups, and the moderate sclerosis group was lower than those in the mild sclerosis group (P<0.05). The levels of serum Lp-PLA2, sdLDL-C, PCSK9, and Cys C in patients with CHD are directly proportional to TG, TC, and LDL-C, and inversely proportional to HDL-C(P<0.05). The levels of serum Lp-PLA2, sdLDL-C, PCSK9, and Cys C in patients with CHD were positively correlated with the de. gree of coronary artery disease (rs=0.56, 0.50, 0.65, 0.71, P<0.05). Conclusion Patients with CHD had abnormal lipid metabolism, and Lp-PLA2, sdLDL-C, PCSK9, and Cys C were closely related to the occurrence of CHD and the degree of lipid metabolism and coro.nary artery disease in patients, which was of great significance for the evaluation of CHD. |
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