| 马佳,林杨.粪便钙卫蛋白联合自然杀伤细胞检测在儿童腹型过敏性紫癜中的诊断价值[J].安徽医药,2026,30(9):1778-1782. |
| 粪便钙卫蛋白联合自然杀伤细胞检测在儿童腹型过敏性紫癜中的诊断价值 |
| Diagnostic value of the combined detection of fecal calprotectin and natural killer cells in children with abdominal Henoch-Sch.nlein purpura |
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| DOI：10.3969/j.issn.1009-6469.2026.09.015 |
| 中文关键词: 紫癜，过敏性 粪便钙卫蛋白 自然杀伤细胞 胃肠道受累 儿童 |
| 英文关键词: Purpura, Henoch-Sch.nlein Fecal calprotectin Natural killer cells Gastrointestinal involvement Children |
| 基金项目:安徽省卫生健康科研项目( AHWJ2024BAe20028) |
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| 中文摘要: |
| 目的探讨粪便钙卫蛋白、自然杀伤( NK)细胞在儿童腹型过敏性紫癜( HSP)病儿中的临床意义。方法回顾性分析 2021年 10月至 2025年 4月中国科学技术大学附属第一医院儿科收治的 104例 HSP病儿的临床资料，根据是否有胃肠道损伤分为腹型组( 66例)和非腹型组( 38例)对两组资料进行分析比较。腹型 HSP依据病情轻重再分为腹型重症组( 41例)和腹型轻症组( 25例)。比较两组病儿 T、B淋巴细，胞亚群， NK细胞及粪便钙卫蛋白水平。采用 logistic回归分析探索腹型 HSP的影响因素，受试者操作特征曲线( ROC曲线)评估粪便钙卫蛋白、 NK细胞联合检测对腹型 HSP的诊断价值。结果腹型 HSP病儿的粪便钙卫蛋白［423.00(182.50，555.50)μg/g比 92.50(29.25，157.00)μg/g］及 NK细胞水平［16.85(13.07，22.72)%比 11.85 |
| 英文摘要: |
| Objective To investigate the clinical significance of fecal calprotectin and natural killer cells (NK) in children with ab. dominal Henoch-Sch.nlein purpura (HSP).Methods A retrospective analysis was performed on the clinical data of 104 children with Henoch-Sch.nlein purpura admitted to the Department of Pediatrics, The First Affiliated Hospital of University of Science and Technol.ogy of China from October 2021 to April 2025. According to the presence of gastrointestinal involvement, the children were divided intothe abdominal group (66 cases) and the non-abdominal group (38 cases), and the data of the two groups were compared. The abdominalHSP group was further subdivided into the severe abdominal subgroup (41 cases) and mild abdominal subgroup (25 cases) based on dis.ease severity. The levels of T and B lymphocyte subsets, NK cells and fecal calprotectin were compared between these two groups. Lo.gistic regression analysis was used to identify the influencing factors of abdominal HSP, and the receiver operating characteristic curve(ROC curve) was applied to evaluate the diagnostic value of the combination of fecal calprotectin and NK cells for abdominal HSP.Re. sults Fecal calprotectin [423.00 (182.50, 555.50) μg/g vs. 92.50 (29.25, 157.00) μg/g] and NK cell levels in children with abdominal HSP [16.85 (13.07, 22.72) % vs. 11.85 (7.37, 19.22) %]were higher than those in the non-abdominal HSP group. The fecal calprotectin level in the severe abdominal subgroup [(481.73±254.85) μg/g vs. (289.58±199.80) μg/g] was higher than that in the mild abdominal subgroup, with a statistically significant difference (P<0.05). Logistic regression analysis showed that fecal calprotectin and NK cells were risk factors for abdominal HSP (P<0.05). The ROC curve demonstrated that the area under the curve (AUC) of the combination offecal calprotectin and NK cells for diagnosing abdominal HSP was 0.89 [95%CI: (0.84, 0.95)], with a sensitivity of 77.3% and specifici. ty of 89.5%, indicating good diagnostic efficacy of this model (P<0.05).Conclusions The combined detection of fecal calprotectin andNK cells can significantly improve the diagnostic performance of abdominal HSP, which facilitates early identification of gastrointesti.nal involvement in children with HSP. Meanwhile, fecal calprotectin has early warning value for the severity of abdominal HSP, provid.ing a basis for early clinical intervention. |
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