| 张茹茹,张艳,霍浩然,等.血清可溶性 B7-H4蛋白、斯坦尼钙调节蛋白 2联合直肠超声在直肠癌鉴别诊断及 TNM分期中的应用价值[J].安徽医药,2026,30(9):1865-1869. |
| 血清可溶性 B7-H4蛋白、斯坦尼钙调节蛋白 2联合直肠超声在直肠癌鉴别诊断及 TNM分期中的应用价值 |
| Value of transrectal ultrasound combined with serum soluble B7-H4 and stanniocalcin 2 in the differential diagnosis and TNM staging of rectal cancer |
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| DOI：10.3969/j.issn.1009-6469.2026.09.031 |
| 中文关键词: 直肠肿瘤 经直肠超声 可溶性 B7-H4蛋白 斯坦尼钙调节蛋白 2 TNM分期 |
| 英文关键词: Rectal neoplasms Transrectal ultrasound Soluble B7-H4 protein Stanniocalcin 2 TNM staging |
| 基金项目:邯郸市科学技术研究与发展计划项目( 23422083207) |
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| 中文摘要: |
| 目的探究血清可溶性 B7-H4蛋白(sB7-H4)、斯坦尼钙调节蛋白 2(STC2)联合经直肠超声在直肠癌鉴别诊断及 TNM分期中的应用价值。方法前瞻性研究。采用随机数字表法选取 2020年 3月至 2022年 6月来邯郸市中心医院治疗的 130例直肠癌病人为研究对象，根据病理学检查结果分为直肠癌组(72例)和非直肠癌组( 58例)，其中直肠癌组病人 TNM分期可分为 Ⅰ期 28例， Ⅱ期 16例， Ⅲ期 28例；另选取同期该院 130例体检健康者为健康组。比较血清 sB7-H4、STC2水平；以受试者操作特征曲线(ROC曲线)分析血清 sB7-H4、STC2水平对直肠癌的诊断价值；以四格表法分析经直肠超声联合血清 sB7-H4、STC2水平对直肠癌的诊断价值。结果直肠癌组舒张末期流速( EDV)水平及血清 sB7-H4［(40.45±6.32)μg/L比( 31.97±4.95)μg/L］、 STC2［( 21.35±5.26)μg/L比( 14.55±4.28)μg/L］水平与非直肠癌组相比明显升高，搏动指数( PI)、阻力指数( RI)水平明显降低( P<0.05)；将直肠癌组和非直肠癌组病人纳入，进行 ROC曲线分析，血清 sB7-H4、STC2诊断直肠癌的曲线下面积( AUC)分别为 0.83、0.78，经直肠超声、血清 sB7-H4、STC2联合诊断的准确度更高( P<0.05)；血清 sB7-H4［( 46.68±7.08)μg/L比( 36.48±5.84) μg/L］、STC2［(26.85±6.25)μg/L比(17.85±4.63)μg/L］在Ⅲ期病人中的水平显著高于 Ⅰ~Ⅱ期(P<0.05)；经直肠超声、血清 sB7-H4、 STC2联合诊断可有效提高诊断直肠癌 TNM分期的灵敏度、准确度( P<0.05)。结论直肠癌病人血清 sB7-H4、STC2水平均上调，经直肠超声联合血清 sB7-H4、STC2在直肠癌鉴别诊断及 TNM分期中具有较高的诊断效能。 |
| 英文摘要: |
| Objective To investigation the application value of serum soluble B7-H4 protein (sB7-H4), stanniocalcin 2 (STC2) com. bined with transrectal ultrasound in the differential diagnosis and TNM staging of rectal cancer.Methods A prospective study wasconducted. A total of 130 patients with rectal cancer who were treated in Handan Central Hospital from March 2020 to June 2022 wereselected as the research objects by random number table method. Based on pathological findings, patients were divided into a rectalcancer group (72 cases) and a non-rectal cancer group (58 cases). The rectal cancer group was further classified by TNM stage: stage Ⅰ(28 cases), stage Ⅱ (16 cases), and stage Ⅲ (28 cases). In addition, 130 healthy individuals undergoing physical examination duringthe same period were selected as a healthy control group. Serum sB7-H4 and STC2 levels were compared among groups. Receiver oper.ating characteristic curve (ROC curve) analysis was used to assess the diagnostic value of serum sB7-H4 and STC2 for rectal cancer,and the fourfold table method was used to evaluate the diagnostic performance of transrectal ultrasound combined with serum sB7-H4 and STC2.Results The rectal cancer group had significantly higher end-diastolic velocity (EDV), serum sB7-H4 [(40.45±6.32) μg/L vs. (31.97±4.95) μg/L], and STC2 [(21.35±5.26) μg/L vs. (14.55±4.28) μg/L] levels, and significantly lower pulsatility index (PI) and re. sistance index (RI) compared with the non-rectal cancer group (all P<0.05). When patients with rectal cancer and non-rectal cancer were included in the ROC curve analysis, the areas under the curve (AUCs) for serum sB7-H4 and STC2 in diagnosing rectal cancer were 0.83 and 0.78, respectively, and the combination of transrectal ultrasound, serum sB7-H4, and STC2 achieved significantly higher diagnostic accuracy (P<0.05). Serum sB7-H4 [(46.68±7.08) μg/L vs. (36.48±5.84) μg/L] and STC2 [(26.85±6.25) μg/L vs. (17.85±4.63) μg/L] levels were significantly higher in stage Ⅲ patients than in stage Ⅰ-Ⅱ patients (P<0.05). The combined use of transrectal ultra. sound, serum sB7-H4, and STC2 effectively improved the sensitivity and accuracy of TNM staging for rectal cancer (P<0.05).Conclu. sions Serum sB7-H4 and STC2 levels are up-regulated in rectal cancer patients. Transrectal ultrasound combined with serum sB7-H4 and STC2 demonstrates high diagnostic efficacy in the differential diagnosis and TNM staging of rectal cancer. |
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