| 张苗苗,郭任维,郑黎强,等.农村人群的年龄与冠心病风险:分析氧化三甲胺的中介作用[J].安徽医药,2026,30(9):1892-1899. |
| 农村人群的年龄与冠心病风险:分析氧化三甲胺的中介作用 |
| Age and coronary heart disease risk in rural populations: evidence from analyzing trimethylamine N-oxide's mediating role |
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| DOI：10.3969/j.issn.1009-6469.2026.09.036 |
| 中文关键词: 冠心病 氧化三甲胺 年龄 中介分析 农村人群 |
| 英文关键词: Coronary heart disease Trimethylamine N-oxide Age Mediation analysis Rural populations |
| 基金项目:山西省应用基础研究计划项目( 201901D111471)；吕梁市平台基地建设项目( 2020ZDSYS16)；吕梁市引进高层次科技人才重点研发项目( 2019115) |
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| 中文摘要: |
| 目的探索氧化三甲胺(TMAO)水平对年龄和冠心病之间关系的中介作用。方法横断面研究。 2021年 6—8月，纳入 1 635名年龄 ≥35岁的中国辽宁省阜新蒙古族自治县农村地区的居民，首先通过 logistic回归模型分别检验年龄、 TMAO水平和冠心病之间的关系，再使用线性回归分析检验年龄和 TMAO之间的关系，最后通过中介分析探究普通人群、老年人群以及肥胖人群中 TMAO的介导作用。结果在控制了所有混杂因素后，多因素 logistic回归分析显示年龄、 TMAO水平与冠心病之间存在显著相关性( P<0.05)。线性回归分析表明年龄与 TMAO呈正相关( P<0.05)。中介分析提示， TMAO是连接年龄与冠心病发展之间的一个重要中介因素［中介占比( PM)=8.7%，P=0.006］；进一步按年龄、身体质量指数( BMI)分层分析显示，这种中介作用仅存在于老年( ≥60岁)人群( PM=12.0%，P=0.040)和超重 /肥胖( BMI≥24 kg/m2)人群( PM=9.2%，P=0.028)中。结论 TMAO参与并介导农村人群的年龄相关冠心病的发生，这种中介作用仅存在于老年人和超重 /肥胖人群中，在中青年人和正常 BMI人群中并未看到这一介导作用。 |
| 英文摘要: |
| Objective To explore the mediating role of trimethylamine N-oxide (TMAO) concentration in the relationship between age and coronary heart disease (CHD).Methods A cross-sectional study was conducted. From June to August 2021, A total of 1,635rural residents aged≥35 years from rural areas of Fuxin Mongolian Autonomous County, Liaoning Province, China, were recruited. First,logistic regression models were used to examine the associations of age and TMAO concentrations with CHD, respectively. Then, linearregression analysis was performed to assess the relationship between age and TMAO levels. Finally, mediation analysis was conductedto explore the mediating role of TMAO in the general population, the elderly population, and the obese population.Results After ad. justing for all potential confounding factors, Multivariate logistic regression analysis revealed significant associations among age, TMAOconcentration, and CHD (P<0.05). Linear regression analysis showed that age was significantly positively correlated with TMAO levels (P<0.05). Mediation analysis showed that TMAO was a significant mediator linking the association between age and CHD development[Proportion mediate (PM)=8.7%, P=0.006]. Further analyses stratified by age and body mass index (BMI) showed that this mediating ef.fect was only present in the older (≥60 years) (PM=12.0%, P=0.040), obese, and overweight (BMI≥24 kg/m2) (PM=9.2%, P=0.028) pop. ulations.Conclusions TMAO participates in and mediates the development of age-related CHD in rural populations. This mediatingeffect is only found in the older, obese, and overweight populations, and is not seen in young.to.middle.aged adults or those with normalBMI. |
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