| 郝振博,边超,李智军.辐射后肿瘤相关成纤维细胞对肿瘤发生发展的影响[J].安徽医药,2026,30(10):1914-1919. |
| 辐射后肿瘤相关成纤维细胞对肿瘤发生发展的影响 |
| Effects of irradiated cancer-associated fibroblasts on tumorigenesis and progression |
| |
| DOI：10.3969/j.issn.1009-6469.2026.10.002 |
| 中文关键词: 肿瘤微环境 肿瘤相关成纤维细胞 放射治疗 放射抵抗性 免疫逃逸 |
| 英文关键词: Tumor microenvironment Cancer-associated fibroblasts Radiotherapy Radioresistance Immune evasion |
| 基金项目:呼和浩特市卫生健康科技计划基金项目( 2024-呼卫科 -012) |
|
| 摘要点击次数: 107 |
| 全文下载次数: 25 |
| 中文摘要: |
| 肿瘤相关成纤维细胞( CAFs)是肿瘤微环境中的关键组成部分，广泛参与肿瘤的增殖、侵袭、转移及免疫逃逸等过程。该研究综述了 CAFs在肿瘤放射治疗中的作用及其机制。研究发现， CAFs具有较强的放射抗性，放疗虽可引起其 DNA损伤，但并未完全影响其对肿瘤的生物活性。辐射可促使 CAFs释放多种细胞因子，如转化生长因子 β(TGF-β)、血管内皮生长因子(VEGF)、白细胞介素 -6(IL-6)等，从而改变肿瘤微环境，增强肿瘤细胞的放疗耐受性。 CAFs的活化可能通过诱导上皮 -间质转化与促进肿瘤干性增强，进一步加剧复发与转移。不同 CAFs亚型在结构重塑及免疫调节中具有不同功能，也对放疗效果产生差异影响。目前，多种 CAFs靶向抑制剂在体内外实验及早期临床研究中展现良好抗肿瘤潜力，联合放射治疗有广阔前景。 |
| 英文摘要: |
| Cancer-associated fibroblasts (CAFs) are pivotal components of the tumor microenvironment and are extensively involved intumor proliferation, invasion, metastasis, and immune evasion. This review summarizes the roles and underlying mechanisms of CAFsin tumor radiotherapy. Studies have shown that CAFs exhibit strong radioresistance; although radiotherapy induces DNA damage inCAFs, it does not fully impair their tumor-promoting functions. Radiation can stimulate CAFs to secrete a variety of cytokines, includ-ing transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), and interleukin-6 (IL-6), thereby modulating thetumor microenvironment and enhancing the radioresistance of tumor cells. Activation of CAFs may induce epithelial-mesenchymal tran-sition and enhance tumor stemness, further promoting recurrence and metastasis. Distinct CAFs subtypes contribute differently to struc-tural remodeling and immune regulation, leading to heterogeneous radiotherapeutic outcomes. Several CAF-targeting inhibitors havedemonstrated promising antitumor potential in in vitro and in vivo studies, as well as in early clinical studies. Combining these inhibi-tors with radiotherapy may represent a promising therapeutic direction. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
