| 许斌,张政.早筛和早诊早治背景下原发性肝癌治疗选择策略的变化[J].安徽医药,2026,30(10):1942-1946. |
| 早筛和早诊早治背景下原发性肝癌治疗选择策略的变化 |
| Changes in treatment strategy for primary liver cancer under the background of early screening and early diagnosis and treatment |
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| DOI：10.3969/j.issn.1009-6469.2026.10.007 |
| 中文关键词: 原发性肝癌 早期诊断 早筛 早诊早治 消融治疗 治疗策略 |
| 英文关键词: Primary liver cancer Early diagnosis Early screening Early diagnosis and treatment Ablation therapy Treat-ment strategy |
| 基金项目:广西中医药大学“岐黄工程”高层次人才团队培育项目( 202411) |
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| 中文摘要: |
| 传统手术切除是肝细胞癌的主要治疗方法，随着肿瘤早筛和早诊早治在肝癌治疗领域的不断深入应用，肝癌治疗的方式、手段和理念正逐步改变。通过对我国庞大肝炎和肝硬化人群开展规范筛查，实现肝癌危险人群精准分层与规范管理，并通过有效血清标志物和影像学检查等技术手段早期预警肝癌，可提升我国肝癌早期诊断率。临床实践中可创建肝癌风险评分模型识别和筛选出中高危罹患肝癌人群，通过新型血清标志物进一步鉴定出肝癌极高危人群，最后应用影像学检查设备如普美显、人工智能( AI)放射组学等进一步完成肝癌早期诊断筛查。消融治疗以其独特的优势在微小肝癌和亚厘米肝癌的治疗中有较大的优势，未来可能会有越来越大的应用前景，手术切除不再是微小肝癌和亚厘米肝癌的唯一治疗选择，早期的微小肝癌和亚厘米肝癌人群将从消融治疗中获益，最终实现提高生存质量、降低肝癌相关死亡率的目标。 |
| 英文摘要: |
| Traditional surgical resection is the primary treatment method for Hepatocellular Carcinoma. With the continuous and in-depth application of early tumor screening, early diagnosis, and early treatment in the field of liver cancer, the methods, means, andconcepts of liver cancer treatment are gradually changing. Through standardized screening of the large population with hepatitis andHepatic cirrhosis in China, precise stratification and standardized management of high-risk populations for liver cancer can beachieved. Early recognition of liver cancer through effective serological markers and imaging examinations can improve the early diag-nosis rate of liver cancer in China. In clinical practice, a liver cancer risk scoring model can be established to identify and screen outpopulations at moderate to high risk of developing liver cancer. Novel serological markers can further identify populations at extremelyhigh risk of liver cancer. Finally, imaging examination equipment such as Gd-EOB-DTPA enhanced MRI and AI radiomics can be used to further complete the early diagnosis and screening of liver cancer. Ablation therapy, with its unique advantages, has significant bene-fits in the treatment of small and sub-centimeter liver cancer, and may have increasingly broad application prospects in the future. Sur-gical resection is no longer the only treatment option for small and sub-centimeter liver cancer. Early-stage small and sub-centimeter liver cancer patients will benefit from ablation therapy, ultimately achieving the goal of improving quality of life and reducing liver can-cer-related mortality. |
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