| 陈昀,耿会欣,杨小杰.血清内毒素、微 RNA-24水平与多囊卵巢综合征病人妊娠结局的关系及联合预测价值分析[J].安徽医药,2026,30(10):1986-1990. |
| 血清内毒素、微 RNA-24水平与多囊卵巢综合征病人妊娠结局的关系及联合预测价值分析 |
| Relationship between serum endotoxin, microRNA-24 levels and pregnancy outcomes in patients with polycystic ovary syndrome and analysis of their combined predictive value |
| |
| DOI：10.3969/j.issn.1009-6469.2026.10.015 |
| 中文关键词: 多囊卵巢综合征 孕妇 内毒素 微 RNA-24 妊娠结局 胰岛素抵抗指数 |
| 英文关键词: Polycystic ovary syndrome Pregnant woman Endotoxin MicroRNA-24 Pregnancy outcome Insulin resistance index |
| 基金项目:河北省医学科学研究重点课题计划项目( 20181336) |
|
| 摘要点击次数: 90 |
| 全文下载次数: 24 |
| 中文摘要: |
| 目的探究血清内毒素、微 RNA-24(miR-24)水平与多囊卵巢综合征( PCOS)病人妊娠结局的关系，并分析二者联合预测妊娠结局的价值，为改善妊娠结局提供参考。方法回顾性研究。选取 2021年 2月至 2023年 8月唐山市妇幼保健院收治的行促排卵治疗受孕的 PCOS病人 192例为 PCOS组，另选取同期 100例健康孕妇为对照组，比较两组血清内毒素、 miR-24。统计 PCOS组妊娠结局情况，比较不同妊娠结局 PCOS病人血清内毒素、 miR-24、性激素［促黄体生长激素( LH)、睾酮］及代谢指标［空腹血糖( FPG)、胰岛素、稳态模型胰岛素抵抗指数( HOMA-IR)］分析血清内毒素、 miR-24与性激素及代谢指标的相关性，绘制受试者操作特征曲线( ROC曲线)获取曲线下面积( AUC)分析血，清内毒素、 miR-24对妊娠结局的预测价值，并分析血清内毒素、 miR-24与 PCOS病人妊娠结局的，关系。结果 PCOS组血清内毒素水平高于对照组， miR-24水平低于对照组( P< 0.05)； 192例 PCOS病人， 43例发生不良妊娠结局。与良好妊娠结局亚组相比，不良妊娠结局亚组血清 LH、睾酮、胰岛素、 FPG、 HOMA-IR较高( P<0.05)；不良妊娠结局亚组血清内毒素高于良好妊娠结局亚组［(0.45±0.08)ng/L比( 0.36±0.07)ng/L］，miR-24低于良好妊娠结局亚组( 0.04±0.01比 0.08±0.02)(P<0.05)； Pearson相关系数法分析显示，血清内毒素与 LH、睾酮、胰岛素、 FPG、HOMA-IR均呈正相关( r=0.68、0.71、0.64、0.72、0.72)miR-24与 LH、睾酮、胰岛素、 FPG、HOMA-IR均呈负相关( r=.0.76、 .0.73、.0.62、.0.67、.0.71)(P<0.05)； ROC曲线显示血清内毒，素、 miR-24联合预测 PCOS病人不良妊娠结局的 AUC最大，为 0.88［95%CI:(0.82，0.92)］，灵敏度为 79.07%、特异度为 87.25%(P<0.05)；血清内毒素高水平时 PCOS病人不良妊娠结局风险较高，血清 miR-24高水平时 PCOS病人不良妊娠结局风险较低，两者同时存在时，交互作用 OR为 20.32，γ为 2.15，呈正向交互作用(P <0.05)。结论 PCOS病人血清内毒素、 miR-24水平明显异常，且与 PCOS病人性激素、胰岛素抵抗有关，联合检测对不良妊娠结局有较高预测价值，内毒素高水平、 miR-24低水平时 PCOS病人不良妊娠结局风险较高。 |
| 英文摘要: |
| Objective To explore the relationship between serum endotoxin, microRNA-24 (miR-24) levels and pregnancy outcomesin patients with polycystic ovary syndrome (PCOS), and to evaluate the combined predictive value of these two markers for such out-comes, so as to provide a reference for improving clinical prognosis.Methods Retrospective study. A total of 192 PCOS patients, whoconceived after ovulation induction therapy and were admitted to Tangshan Maternal and Child Health Hospital from February 2021 toAugust 2023, were selected as the PCOS group, and 100 healthy pregnant women during the same period were selected as the controlgroup. Serum endotoxin and miR-24 levels were compared between the two groups. The pregnancy outcomes of the PCOS group werestatistically analyzed, and serum endotoxin, miR-24, sex hormones [luteinizing hormone (LH), testosterone (T)], and metabolic indica-tors [fasting plasma glucose (FPG), insulin (INS), and homeostatic model assessment of insulin resistance (HOMA-IR)] were compared between PCOS patients with different pregnancy outcomes. The correlations of serum endotoxin and miR-24 with sex hormones and metabolic indicators were analyzed, the receiver operating characteristic curves (ROC curves) of the subjects were plotted, and the areaunder the curve (AUC) was obtained to evaluate the predictive value of serum endotoxin and miR-24 for pregnancy outcomes. The rela-tionship between serum endotoxin, miR-24, and pregnancy outcomes in PCOS patients was also analyzed.Results The serum endotox-in level in the PCOS group was significantly higher than that in the control group, while the miR-24 level was significantly lower (P< 0.05). Among the 192 PCOS patients, 43 experienced adverse pregnancy outcomes. Compared with the subgroup with favorable preg-nancy outcomes, the subgroup with adverse pregnancy outcomes had higher serum levels of LH, T, INS, FPG, and HOMA-IR (P< 0.05).The serum endotoxin level in the adverse pregnancy outcome subgroup was higher than that in the favorable pregnancy outcome sub-group [(0.45±0.08) ng/L vs. (0.36±0.07) ng/L], and the miR-24 level was lower (0.04±0.01 vs. 0.08±0.02) (P<0.05). Pearson correlation analysis showed that serum endotoxin was positively correlated with LH, T, INS, FPG, and HOMA-IR (r = 0.68, 0.71, 0.64, 0.72, 0.72, respectively), while miR-24 was negatively correlated with LH, T, INS, FPG, and HOMA-IR (r=.0.76, .0.73, .0.62, .0.67, .0.71, re-spectively) (P< 0.05). ROC curve analysis showed that the combination of serum endotoxin and miR-24 yielded the largest AUC for pre-dicting adverse pregnancy outcomes in patients with PCOS, with a value of 0.88 [95%CI: (0.82, 0.92)], a sensitivity of 79.07%, and a specificity of 87.25% (P<0.05). Patients with PCOS and high serum endotoxin levels had a higher risk of adverse pregnancy outcomes,while those with high serum miR-24 levels had a lower risk; when both markers were present simultaneously, the interaction OR was |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
