| 吴海燕,于壮,陈靓,等.西安地区 2所三甲医院孕早期孕妇 TORCH感染状况及影响因素调查[J].安徽医药,2026,30(10):1997-2001. |
| 西安地区 2所三甲医院孕早期孕妇 TORCH感染状况及影响因素调查 |
| TORCH infection status and influencing factors in early pregnant women in two grade-A tertiary hospitals of Xi'an region |
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| DOI：10.3969/j.issn.1009-6469.2026.10.017 |
| 中文关键词: TORCH感染 孕早期 孕妇 影响因素分析 不良妊娠史 |
| 英文关键词: TORCH infection Early pregnancy Pregnant woman Influence factor Root cause analysis Adverse pregnancy history |
| 基金项目:陕西省重点研发计划项目( 2023-YBSF-320) |
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| 中文摘要: |
| 目的调查西安地区 2所三甲医院孕早期孕妇 TORCH［弓形虫( TOX)、风疹病毒( RV)、巨细胞病毒(CMV)、单纯疱疹病毒( HSV)Ⅰ/Ⅱ型］感染状况，并分析相关影响因素。方法回顾性研究。选择 2022年 1月至 2024年 5月西北妇女儿童医院和西安医学院第二附属医院开展产前检查的 2 064例孕早期(孕周 <14周)孕妇，通过电化学发光法对孕妇 TORCH-免疫球蛋白 M(IgM)抗体予以检测，并根据检测结果分成 TORCH组和非 TORCH组。对两组 11项资料开展比较，将差异有统计学意义的指标纳入 logistic回归模型，筛查出孕早期孕妇 TORCH感染的相关因素。结果 TORCH感染 158例，其中 TOX感染 21例， RV感染 29例， CMV感染 47例， HSV感染 61例，总感染率为 7.66%。TORCH组和非 TORCH组居住地(城市 26.58%、农村 73.42%比城市 36.78%、农村 63.22%)、不良妊娠史( 35.44%比 25.18%)、动物接触史( 36.08%比 24.76%)、合并妊娠高血压综合征情况(7.59%比 3.93%)、合并妊娠期糖尿病情况( 9.49%比 4.62%)、检测季节差异有统计学意义( P<0.05)。 logistic回归分析显示，居住地为农村［ OR=2.41，95%CI:(1.26，4.59)］、有不良妊娠史［ OR=2.66，95%CI:(1.43，4.92)］、有动物接触史［ OR=3.18，95%CI:(1.77，5.70)］、有妊娠高血压综合征［ OR=2.25，95%CI:(1.18，4.27)］、有妊娠期糖尿病［ OR=2.75，95%CI:(1.50，5.04)］为孕早期孕妇 TORCH感染的危险因素。结论西安地区 2所三甲医院孕早期孕妇有发生 TORCH感染的较高风险，感染病原体以 CMV 和 HSV为主，危险因素主要为居住地为农村、有不良妊娠史、有动物接触史、有妊娠高血压综合征及妊娠期糖尿病。故应对具有上述特征的孕妇做好 TORCH感染知识的教育，并注重早期筛查及治疗，以规避或减小 TORCH感染对孕妇妊娠结局的影响。 |
| 英文摘要: |
| Objective To investigate the infection status of TORCH [Toxoplasma gondii (TOX), rubella virus (RV), cytomegalovirus(CMV), and herpes simplex virus (HSV) types Ⅰ/Ⅱ] in early pregnant women at two grade-A tertiary hospitals of Xi'an region, and to analyze the relevant influencing factors.Methods Retrospective study. A total of 2,064 pregnant women in the first trimester (gesta-tional age <14 weeks) who underwent prenatal examination at Northwest Women and Children's Hospital and the Second AffiliatedHospital of Xi'an Medical University from January 2022 to May 2024 were enrolled. TORCH-specific immunoglobulin M (IgM) antibod-ies were detected by electrochemiluminescence immunoassay. Based on the test results, the women were divided into the TORCH-posi-tive group and the TORCH-negative group. A total of 11 data points were compared between the two groups, and the indicators with sta-tistically significant differences were incorporated into a logistic regression model to screen for factors associated with TORCH infectionin early pregnancy.Results There were 158 cases of TORCH infection, including 21 cases of TOX infection, 29 cases of RV infection,47 cases of CMV infection, and 61 cases of HSV infection, yielding a total infection rate of 7.66%. There were statistically significantdifferences between the TORCH-positive group and the TORCH-negative group in terms of place of residence (urban areas: 26.58% vs. 36.78%; rural areas: 73.42% vs. 63.22%), history of adverse pregnancy outcomes (35.44% vs. 25.18%), history of animal contact (36.08% vs. 24.76%), pregnancy-induced hypertension (7.59% vs. 3.93%), gestational diabetes mellitus (9.49% vs. 4.62%), and testing season (P<0.05). Logistic regression analysis results showed that residing in rural areas [OR=2.41, 95%CI: (1.26, 4.59)], history of ad-verse pregnancy outcomes [OR=2.66, 95%CI: (1.43, 4.92)], history of animal contact [OR=3.18, 95%CI: (1.77, 5.70)], pregnancy-in-duced hypertension [OR=2.25, 95%CI: (1.18, 4.27)] and gestational diabetes mellitus [OR=2.75, 95%CI: (1.50, 5.04)] were risk factors for TORCH infection in early pregnancy.Conclusions Pregnant women in early pregnancy at two grade-A tertiary hospitals in Xi'anregion have a higher risk of TORCH infection, with CMV and HSV being the predominant pathogens. The primary risk factors are resid-ing in rural areas, history of adverse pregnancy outcomes, history of animal contact, pregnancy-induced hypertension and gestational di-abetes mellitus. Therefore, health education on TORCH infection should be provided to pregnant women with the above-mentioned characteristics, and early screening and timely intervention should be emphasized to avoid or reduce the impact of TORCH infection onpregnancy outcomes. |
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