| 姜如,周凌燕,章臻翊,等.穴位埋线治疗单纯性肥胖症的疗效及对血清 GDF15、 GFRAL水平的影响[J].安徽医药,2026,30(10):2034-2040. |
| 穴位埋线治疗单纯性肥胖症的疗效及对血清 GDF15、 GFRAL水平的影响 |
| The therapeutic effect of acupoint catgut embedding on obesity and its impact on serum GDF15 and GFRAL levels |
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| DOI：10.3969/j.issn.1009-6469.2026.10.024 |
| 中文关键词: 单纯性肥胖 穴位埋线 糖代谢 脂代谢 身体质量指数 生活质量 |
| 英文关键词: Simple obesity Acupoint catgut embedding therapy Glucose metabolism Lipid metabolism Body mass index Quality of life |
| 基金项目:湖南省自然科学基金项目( 2026JJ82305)；湖南省临床医疗技术创新引导项目( 2020SK52902)；长沙市自然科学基金 |
| 作者 | 单位 | E-mail | | 姜如 | 长沙市第三医院湖南大学附属长沙医院, 中西医结合科,湖南长沙 410015 | | | 周凌燕 | 长沙市第三医院湖南大学附属长沙医院, 中西医结合科,湖南长沙 410015 | zlingyanzi@126.com | | 章臻翊 | 长沙市第三医院临床营养科,湖南长沙 410015 | | | 周晓英 | 长沙市第三医院湖南大学附属长沙医院, 中西医结合科,湖南长沙 410015 | | | 谢莉娜 | 长沙市第三医院湖南大学附属长沙医院, 中西医结合科,湖南长沙 410015 | | | 胡彪 | 长沙市第三医院儿科,湖南长沙 410015 | |
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| 中文摘要: |
| 目的分析穴位埋线治疗单纯性肥胖症的疗效及对血清生长分化因子 15(GDF15)、生长分化因子 15特异性受体(GFRAL)水平的影响。方法前瞻性研究。选取 2023年 5月至 2024年 10月长沙市第三医院(湖南大学附属长沙医院)收治的 150例单纯性肥胖症病人，按随机数字表法分组，两组均开展全生活方式管理，在此基础上对照组 75例行假穴位埋线治疗，研究组 75例行穴位埋线治疗，对比两组临床疗效、基础指标、糖脂代谢、血清 GDF15、GFRAL水平、生活质量及安全性。结果研究组总有效率较对照组高( 96.00%比 81.33%，P<0.05)；研究组治疗 3个月后身体质量指数( BMI)、腰臀比及体脂率较对照组低( P<0.05)；研究组治疗 3个月后低密度脂蛋白胆固醇( LDL-C)、总胆固醇( TC)、甘油三酯( TG)、空腹血糖( FPG)、糖化血红蛋白(HbA1c)及空腹胰岛素( FINS)水平较对照组低，高密度脂蛋白胆固醇( HDL-C)水平较对照组高( P<0.05)；两组治疗 3个月后 GDF15、GFRAL水平较同组治疗前均降低，且研究组降低更明显( P<0.05)；研究组治疗 3个月后健康调查简表( SF-36)评分较对照组更高( P<0.05)；两组不良反应发生率比较，差异无统计学意义( 6.66%比 9.33%，P>0.05)。结论单纯性肥胖症病人应用穴位埋线治疗，有利于疗效提高，降低病人 BMI、腰臀比及体脂率，可改善糖脂代谢，降低血清 GDF15、GFRAL水平，提高病人生活质量，且安全性良好。 |
| 英文摘要: |
| Objective To analyze the efficacy of acupoint catgut embedding in treating simple obesity and its effects on serum levelsof growth differentiation factor 15 (GDF15) and GDNF family receptor alpha-like (GFRAL). Methods Prospective study. A total of150 patients with simple obesity admitted to The Third Hospital of Changsha from May 2023 to October 2024 were enrolled and ran-domly divided into two groups using a random number table method. Both groups received comprehensive lifestyle management. Onthis basis, the control group (n=75) received sham acupoint catgut embedding, while the study group (n=75) received acupoint catgutembedding. The clinical efficacy, basic indicators, glycolipid metabolism, serum GDF15 and GFRAL levels, quality of life, and treat-ment safety were compared between the two groups. Results The total efficacy rate in the study group was significantly higher than that in the control group (96.00% vs. 81.33%, P<0.05). After 3 months of treatment, the study group exhibited lower body mass index (BMI), waist-to-hip ratio (WHR), and body fat percentage compared with the control group (P<0.05). The levels of low-density lipopro-tein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), andfasting insulin (FINS) in the study group were significantly lower than those in the control group after 3 months of treatment, while thehigh-density lipoprotein cholesterol (HDL-C) level was significantly higher (all P<0.05). After 3 months of treatment, serum GDF15 andGFRAL levels decreased in both groups compared with baseline, with a more pronounced reduction in the study group (all P<0.05). The study group also had significantly higher scores on the 36-Item Short Form Health Survey (SF-36) after 3 months of treatment com-pared with the control group (P<0.05). No statistically significant difference was observed in the incidence of adverse reactions between the two groups (6.66% vs. 9.33%, P>0.05). Conclusion Acupoint catgut embedding is beneficial for enhancing therapeutic efficacy inpatients with simple obesity, reducing BMI, WHR, and body fat percentage, promoting glycolipid metabolism, lowering serum GDF15and GFRAL levels, and improving quality of life, with a good safety profile. |
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