| 张渤,孙美玲,张静,等.肥胖病人血清 sdLDL-C、SDC4水平与冠心病的相关性研究[J].安徽医药,2026,30(10):2045-2049. |
| 肥胖病人血清 sdLDL-C、SDC4水平与冠心病的相关性研究 |
| Correlation between serum sdLDL-C, SDC4 and coronary heart disease in obese patients |
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| DOI：10.3969/j.issn.1009-6469.2026.10.026 |
| 中文关键词: 肥胖 小而密低密度脂蛋白胆固醇(sdLDL-C) 多配体蛋白聚糖 4(SDC4) 冠心病 相关性 |
| 英文关键词: Obesity Small, dense low-density lipoprotein cholesterol (sdLDL-C) Syndecan-4 (SDC4) Coronary heart disease Correlation |
| 基金项目:河北省医学科学研究课题计划资助项目( 20232095) |
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| 中文摘要: |
| 目的探究肥胖病人血清小而密低密度脂蛋白胆固醇( sdLDL-C)、多配体蛋白聚糖 4(SDC4)水平与冠心病的相关性。方法前瞻性研究。选取 2022年 8月至 2023年 10月在沧州市人民医院接受治疗的肥胖冠心病病人( n=103)作为肥胖 CHD组，另选择同期在该院健康体检的单纯肥胖者( n=103)作为对照组。测定血清 sdLDL-C、SDC4水平；血清 sdLDL-C、SDC4与 Gensini评分的相关性采用 Pearson法分析；肥胖冠心病病人病情严重程度的影响因素采用 logistic回归模型。结果肥胖 CHD组血清 sdLDL-C［( 26.04±2.78)mg/L比( 15.53±1.61)mg/L］、 SDC4［( 14.26±2.15)μg/L比( 7.19±0.68)μg/L］水平高于对照组( P<0.05)。肥胖冠心病病人低危、中危、高危组血清 sdLDL-C、SDC4水平逐渐升高( P<0.05)。肥胖冠心病病人血清 sdLDL-C、SDC4水平与 Gensini评分存在正相关性( rs=0.46、0.40，P<0.001)。肥胖冠心病病人低中危组和高危组 BMI、Gensini评分差异有统计学意义( P<0.05)。血清 sdLDL-C、SDC4、BMI是肥胖冠心病病人病情严重程度的危险因素( P<0.05)。结论肥胖冠心病病人血清 sdLDL-C、SDC4水平升高，与冠心病病情严重程度有关。 |
| 英文摘要: |
| Objective To investigate the correlation between serum levels of small dense low-density lipoprotein cholesterol (sdLDL-C) and syndecan-4 (SDC4) and coronary heart disease (CHD) in obese patients.Methods Prospective study. Obese CHD patients (n= 103) who received treatment at Cangzhou People's Hospital from August 2022 to October 2023 were labeled as obese CHD group, andsimple obese patients (n=103) who underwent health checkups at the same hospital during the same period were labeled as controlgroup. The serum levels of sdLDL-C and SDC4 were measured. The correlation between serum sdLDL-C, SDC4 and Gensini score wasanalyzed using Pearson correlation. The factors influencing the severity of CHD in obese patients were analyzed using logistic regres-sion.Results The serum levels sdLDL-C [(26.04±2.78) mg/L vs. (15.53±1.61) mg/L] and SDC4 [(14.26±2.15) μg/L vs. (7.19±0.68) μg/ L] in the obese CHD group were significantly higher than those in the control group (P<0.05). In the obese CHD patients, serum sdLDL-C and SDC4 levels gradually increased in the low-, medium-, and high-risk groups (all P<0.05). Serum sdLDL-C and SDC4 levels in obese CHD patients were positively correlated with the Gensini score (r=0.46, 0.40, respectively; P<0.001). Body mass index (BMI) sand the Gensini score were not statistically significantly different between the low-and medium-risk groups and high-risk group (P<0.05). Serum sdLDL-C, SDC4, and BMI were identified as risk factors for the severity of CHD in obese patients (P<0.05).Conclusion |
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