| 陈东津,岳红梅,田凤,等.体质量校正腰围指数在阻塞性睡眠呼吸暂停风险与抑郁症状的中介效应分析[J].安徽医药,2026,30(10):2056-2060. |
| 体质量校正腰围指数在阻塞性睡眠呼吸暂停风险与抑郁症状的中介效应分析 |
| Mediating effect of weight-adjusted waist circumference index on the risk of obstructive sleep apnea and depressive symptoms |
| |
| DOI：10.3969/j.issn.1009-6469.2026.10.028 |
| 中文关键词: 身体质量指数 腰围 阻塞性睡眠呼吸暂停 抑郁症状 中介效应 横断面研究 美国国家健康和营养调查(NHANES) |
| 英文关键词: Body mass index Waist circumference Obstructive sleep apnea Depressive symptoms Mediation effect Cross-sectional study National health and nutrition survey(NHANES) |
| 基金项目:甘肃省自然科学基金项目( 1506RJZA254)；甘肃省科技计划(科技重大专项计划)项目( 22ZD1FA001)；省级重大专项孵育项目( ldyyyn2022-77) |
| 作者 | 单位 | E-mail | | 陈东津 | 兰州大学第一临床医学院,甘肃兰州,730000 | | | 岳红梅 | 兰州大学第一临床医学院,甘肃兰州,730000
兰州大学第一医院呼吸与危重症医学科,甘肃兰州 730000 | yuehongmei@sina.com | | 田凤 | 兰州大学第一临床医学院,甘肃兰州,730000 | | | 马媛媛 | 兰州大学第一临床医学院,甘肃兰州,730000 | | | 秦亚茹 | 兰州大学第一临床医学院,甘肃兰州,730000 | |
|
| 摘要点击次数: 94 |
| 全文下载次数: 20 |
| 中文摘要: |
| 目的探讨体质量校正腰围指数(WWI)在阻塞性睡眠呼吸暂停(OSA)风险和抑郁症状的中介效应，为抑郁症状的预防和缓解提供数据参考。方法横断面研究。 2024年 5—10月选取美国国家健康和营养调查数据( NHANES)2005—2006年、 2007—2008年、 2015—2016年、 2017—2018年共 4个调查周期中 ≥20岁 11 343例调查者作为研究对象。分别采用睡眠健康量表问卷( STOP-BANG问卷)评估 OSA风险，抑郁症自我评估量表( PHQ-9)评估抑郁症状严重程度，根据腰围与体质量计算 WWI。使用相关分析、回归分析探讨 OSA风险、 WWI、抑郁症状之间的关系， bootstrap检验变量与 WWI之间的中介效应。结果研究共纳入 11 343例研究对象，男性 5 956例( 52.51%)，女性 5 387例(47.49%)。被认为患有抑郁症 893例( 7.87%)。与非抑郁症者相比，抑郁症病人中女性、吸烟、饮酒病人占比更大， WWI更高［ 124.38(111.61，138.67)cm/132.13)cm/kg比 119.51(107.63， kg，P<0.05］。 OSA风险与抑郁症状呈正相关关系( r=0.13，P<0.001)，OSA风险评分与 WWI呈正相关( r=0.51，P<0.001)，WWI与抑郁症状呈正相关关系( r=0.08，P<0.001)。中介效应结果显示， WWI［效应值 =0.05，95%CI:(0.02，0.08)］显著中介了 OSA风险和抑郁症状之间的联系。结论 OSA风险和 WWI均是抑郁症状的影响因素， WWI在 OSA风险与抑郁症状之间起部分中介作用。 |
| 英文摘要: |
| Objective To explore the mediating effect of weight-adjusted waist circumference index (WWI) on the risk of obstructivesleep apnea (OSA) and depressive symptoms, and to provide data for the prevention and remission of depressive symptoms.Methods Cross-sectional study. From May to October 2024, a total of 11,343 participants aged ≥ 20 years were selected from the National healthand nutrition examination survey (NHANES) in 2005-2006, 2007-2008, 2015-2016, and 2017-2018. The risk of OSA was evaluated re-spectively by using the sleep health questionnaire (STOP-BANG Questionnaire), and patient health questionnaire-9 (PHQ-9) was usedto assess the severity of depressive symptoms. WWI was calculated based on waist circumference and weight. Correlation analysis andregression analysis were used to explore the relationship between OSA risk, WWI and depressive symptoms, and bootstrap test wasused to test the mediating effect between variables and WWI.Results A total of 11 343 subjects were included in this study, including5 956 males (52.51%) and 5 387 females (47.49%). 893 (7.87%) were considered to have depression. Compared with non-depressionpatients, depression patients had a larger proportion of women, smoking and drinking, and higher WWI [124.38 (111.61, 138.67) cm/kg vs. 119.51 (107.63, 132.13) cm/kg,P<0.05]. There was a positive correlation between OSA risk and depressive symptoms (r= 0.13, P<0.001). OSA risk score was positively correlated with WWI (r=0.51, P<0.001), and WWI was positively correlated with depres-sive symptoms (r=0.08, P<0.001). WWI significantly mediated the association between OSA risk and depressive symptoms [effect size=0.05, 95%CI: (0.02, 0.08)].Conclusion Both OSA risk and WWI are the influencing factors of depressive symptoms, and WWI playsa partial mediating role between OSA risk and depressive symptoms. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
