| 张泽,庞磊,王泽,等.雄激素、雄激素受体与膀胱癌和顺铂化疗耐药性的研究进展[J].安徽医药,2026,30(11):2129-2133. |
| 雄激素、雄激素受体与膀胱癌和顺铂化疗耐药性的研究进展 |
| Androgens and androgen receptors and resistance to cisplatin chemotherapy in bladder cancer |
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| DOI：10.3969/j.issn.1009-6469.2026.11.002 |
| 中文关键词: 膀胱肿瘤 雄激素 雄激素受体 顺铂 耐药性 |
| 英文关键词: Urinary bladder neoplasms Androgen Androgen receptor Cisplatin Drug resistance |
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| 中文摘要: |
| 膀胱癌在男女之间发病率不同，男性比女性发病率高，但女性病人的预后往往比男性更差。这种差别可能不能完全归因于吸烟习惯、职业因素及年龄变化等，雄激素也可能是原因之一。雄激素在男性前列腺癌和睾丸癌中的作用已得到了充分的证实。雄激素及其受体也存在于人的膀胱组织中，它在膀胱癌发生发展中的作用，以及对膀胱癌病人化疗药物耐药性产生的关系，却备受争议。该文旨在概述雄激素及其受体在膀胱癌起始、增殖及转移中的作用机制，及其对膀胱癌病人术后顺铂化疗耐药性的影响，以便更好地使用这些药物。 |
| 英文摘要: |
| The incidence of bladder cancer varies between men and women, with men having a higher incidence than women, but fe-male patients tend to have a worse prognosis than men. This difference may not be entirely attributable to smoking habits, occupationalfactors and changes in age, and androgens may also be one of the contributing factors. The role of androgens in prostate and testicularcancer in men is well established. Androgens and their receptors are also present in human bladder tissue. However, the role of andro-gens in the development of bladder cancer and the relationship with chemotherapy resistance in bladder cancer patients remains contro-versial. The aim of this review is to summarize the mechanism of initiation,proliferation and metastasis of androgens and their receptorsin bladder carcinogenesis,as well as the effect on resistance to postoperative cisplatin chemotherapy in bladder cancer patients, in orderto make better use of these drugs. |
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