| 李岩,尹静一,马胜辉,等.系统性炎症指标在结直肠癌诊疗中的应用现状[J].安徽医药,2026,30(11):2134-2139. |
| 系统性炎症指标在结直肠癌诊疗中的应用现状 |
| Current status of systemic inflammatory indicators in the diagnosis and treatment of colorectal cancer |
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| DOI：10.3969/j.issn.1009-6469.2026.11.003 |
| 中文关键词: 结直肠肿瘤 系统性炎症指标 诊断 预后 |
| 英文关键词: Colorectal neoplasms Systemic inflammatory indicator Diagnosis Prognosis |
| 基金项目:河北省医学科学研究课题计划( 20211022) |
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| 中文摘要: |
| 结直肠癌(CRC)是常见的恶性肿瘤，具有较高的发病率和病死率。近年来，众多研究表明，系统性炎症反应在结直肠癌的发生、发展及预后中发挥着关键作用。系统性炎症反应不仅与肿瘤微环境密切相关，还在肿瘤免疫逃逸、侵袭性发展及转移过程中，扮演着重要调控角色。多种炎症指标，如中性粒细胞与淋巴细胞比值( NLR)、血小板与淋巴细胞比值( PLR)、系统免疫炎症指数(SII)及格拉斯哥预后评分( GPS)等，已被广泛用于评估系统性炎症状态，在 CRC的诊断、预后预测及治疗监测中具有显著的临床应用价值。现综述炎症指标在 CRC诊疗中的应用现状及最新进展，探讨其潜在临床应用前景。 |
| 英文摘要: |
| Colorectal cancer(CRC)is a common malignant tumor with a high incidence and mortality rate. In recent years，numerous studies have shown that systemic inflammatory response plays a crucial role in the initiation，progression，and prognosis of CRC.Sys-temic inflammatory response is not only closely associated with the tumor microenvironment，but also plays a critical regulatory role in tumor immune evasion，aggressive progression，and metastasis. Various inflammatory markers，such as the neutrophil-to-lymphocyte ratio(NLR)，platelet-to-lymphocyte ratio(PLR)，systemic immune-inflammation index(SII)，and Glasgow Prognostic Score(GPS)， have been widely used to assess systemic inflammatory status. These markers have significant clinical value in the diagnosis，prognosis prediction，and treatment monitoring of colorectal cancer. This article aims to review the current status and recent advances in the ap-plication of inflammatory markers in the diagnosis and treatment of CRC，and to explore their potential clinical application prospects. |
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