| 赵琼印,孙美妹,李明福,等.巨噬细胞极化在变应性鼻炎发病作用中的研究进展[J].安徽医药,2026,30(11):2163-2168. |
| 巨噬细胞极化在变应性鼻炎发病作用中的研究进展 |
| Research progress on the role of macrophage polarization in the pathogenesis of allergic rhinitis |
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| DOI：10.3969/j.issn.1009-6469.2026.11.008 |
| 中文关键词: 变应性鼻炎 巨噬细胞 极化 非编码 RNA 辅助性 T细胞 树突状细胞 |
| 英文关键词: Allergic rhinitis Macrophages Polarization Non-coding RNA Helper T cell Dendritic cells |
| 基金项目:海南省自然科学基金( 821MS142) |
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| 中文摘要: |
| 巨噬细胞( Mφ)作为重要的免疫效应细胞，在变应性鼻炎( AR)的发病过程中发挥关键作用。研究表明，非编码 RNA(ncRNA)及其相关调控因子在 Mφ的极化和功能调节中扮演着重要角色。 ncRNA通过调控多条信号通路，影响 Mφ的极化状态，进而在 AR的炎症反应中产生显著影响。此外，其他免疫细胞如辅助性 T细胞( Th)和树突状细胞( DC)以及它们分泌的细胞外产物，通过相关信号通路和作用因子，进一步调节 Mφ的功能和极化。这些相互作用不仅促进 AR的炎症，反应，还可能加重临床症状，影响疾病的进程。 |
| 英文摘要: |
| Macrophages (Mφ), as pivotal immune effector cells, play a critical role in the pathogenesis of allergic rhinitis (AR). Studieshave demonstrated that non-coding RNAs (ncRNAs) and their associated regulatory factors are instrumental in modulating the polariza-tion and functional dynamics of Mφ. By influencing multiple signaling pathways, ncRNAs can alter the polarization states of Mφ, there-by significantly impacting the inflammatory response characteristic of AR. Additionally, other immune cells, including helper T cells(Th cells) and dendritic cells (DCs), as well as the extracellular mediators they secrete, further modulate Mφ function and polarizationthrough specific signaling pathways and regulatory factors. These intricate interactions not only exacerbate the inflammatory responsein AR but may also intensify clinical symptoms and influence the overall progression of the disease. |
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