| 康茜,郎筠渊,马凯.13号染色体缺失在多发性骨髓瘤中的研究进展[J].安徽医药,2026,30(11):2173-2178. |
| 13号染色体缺失在多发性骨髓瘤中的研究进展 |
| Research progress on chromosome 13 deletion in multiple myeloma |
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| DOI：10.3969/j.issn.1009-6469.2026.11.010 |
| 中文关键词: 多发性骨髓瘤 13号染色体 RB1 MiR-15a/miR-16-1 DIS3 发病机制 荧光原位杂交法 |
| 英文关键词: Multiple myeloma Chromosome 13 RB1 MiR-15a/miR-16-1 DIS3 Pathogenesis Fluorescence in situ hybridization |
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| 中文摘要: |
| 多发性骨髓瘤( MM)作为一种由单克隆浆细胞恶性增生引起的血液系统肿瘤，在血液恶性肿瘤中位居第二，多见于老年人群，至今缺乏根治性治疗方案。尽管 MM的具体发病机制尚未得到全面阐释，但累积的研究数据显示，染色体异常在 MM发病中扮演了核心角色，涉及染色体结构和数目的多样变异，这些遗传学的异质性与 MM的生物学特性密切相关。特别是 13号染色体的缺失［del(13)］主要表现为 13q14区域的缺失。这种缺失不仅是 MM中一种常见的早期遗传学异常，而且伴随疾病的整个进展过程。因此，探，讨 13号染色体上相关基因在 MM发病机制中的作用，旨在为理解 MM的复杂病理生物学特性、指导临床治疗决策以及未来研究方向提供重要的参考信息。 |
| 英文摘要: |
| Multiple Myeloma (MM), a hematological malignancy characterized by the malignant proliferation of monoclonal plasmacells, is the second most common blood cancer and primarily affects the elderly, with no curative treatment available as of now. Al-though the specific pathogenesis of MM remains unclear, extensive research data suggest that chromosomal abnormalities are pivotal inthe development of MM, featuring diverse variations in chromosome structure and number. These genetic heterogeneities are closely as-sociated with the biological characteristics of MM, notably the deletion of chromosome 13 [del(13)], which is typically characterized bya loss in the 13q14 region. This deletion is not only a common early genetic abnormality in MM but also persists throughout the dis‐ease's progression. Therefore, this review aims to explore the role of genes on chromosome 13 in the pathogenesis of MM, providing cru-cial reference information for elucidating the complex pathological biology of MM, informing clinical treatment decisions, and shapingfuture research directions. |
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