| 胡桂琼,祝佳,袁琴.载脂蛋白 A1、载脂蛋白 B对多囊卵巢综合征激素替代 -冻融胚胎移植临床妊娠率的影响[J].安徽医药,2026,30(11):2199-2204. |
| 载脂蛋白 A1、载脂蛋白 B对多囊卵巢综合征激素替代 -冻融胚胎移植临床妊娠率的影响 |
| The effect of ApoA1 and ApoB on the clinical pregnancy rate of hormone replacement-frozen embryo transfer in PCOS patients |
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| DOI：10.3969/j.issn.1009-6469.2026.11.015 |
| 中文关键词: 多囊卵巢综合征 激素替代 -冻融胚胎移植 临床妊娠率 载脂蛋白 A1 载脂蛋白 B |
| 英文关键词: Polycystic ovary syndrome Hormone replacement-frozen embryo transfer Clinical pregnancy rate Apolipoprotein A1 Apolipoprotein B |
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| 中文摘要: |
| 目的探讨载脂蛋白( Apo)A1、ApoB对多囊卵巢综合征(PCOS)病人激素替代 -冻融胚胎移植( HRT-FET)临床妊娠率的影响。方法对 2020年 10月至 2023年 10月乐山市妇幼保健院行 HRT-FET治疗的 123周期 PCOS病人的临床资料进行回顾性分析，根据医院生殖科数据库记录的临床结局情况(胚胎移植后 30~40 d超声检查判断)将病人分为妊娠组 77例与非妊娠组 46例。比较两组行 HRT-FET治疗前血清 ApoA1、ApoB水平、 ApoB/ApoA1比值及其他相关资料，重点分析 ApoA1、ApoB及其比值对临床妊娠率的影响。结果非妊娠组身体质量指数( BMI)［( 25.49±2.11)kg/m2比( 24.37±2.09)kg/m2］、胰岛素抵抗指数(HOMA-IR)(4.68±1.01比 4.02±0.87)、低密度脂蛋白胆固醇( LDL-C)［( 2.99±0.84)mmol/L比( 2.51±0.63)mmol/L］、 ApoB水平［( 1.15±0.25)g/L比( 0.93±0.21)g/L］、 ApoB/ApoA1比值高于妊娠组， 2枚胚胎移植数占比低于妊娠组( 10.87%比 25.97%，P<0.05)；两组血清 ApoA1水平比较，差异无统计学意义( P>0.05)。 logistic回归分析， ApoB、ApoB/ApoA1比值均与 PCOS病人 HRT-FET临床妊娠率有关( P<0.05)。平滑曲线拟合显示 ApoB对 PCOS病人 HRT-FET临床未妊娠率的影响呈上升的曲线关系； ApoB/ApoA1比值对 PCOS病人 HRT-FET临床妊娠率的影响呈先上升后逐步趋于平缓的曲线关系。结论 ApoB、ApoB/ ApoA1比值与 PCOS病人 HRT-FET临床妊娠率存在一定的关联性，早期监测 ApoB、ApoB/ApoA1比值情况可能对提示临床妊娠率变化有益。 |
| 英文摘要: |
| Objective To explore the effects of Apo A1 and ApoB on the clinical pregnancy rate of hormone replacement-frozen em-bryo transfer (HRT-FET) cycle in patients with polycystic ovary syndrome (PCOS).Methods A retrospective analysis was conducted on the clinical data of 123 cycles of PCOS patients who received HRT-FET treatment in Leshan Maternal and Child Health Hospitalfrom October 2020 to October 2023. According to the clinical outcomes recorded in the hospital's reproductive database (determinedby ultrasound examination 30-40 days after embryo transfer), patients were divided into pregnancy group (n=77) and non pregnancy group (n=46). Serum levels of ApoA1, ApoB, ApoB/ApoA1 ratio and other relevant data were compared between the two groups before HRT-FET treatment, focusing on the effects of ApoA1, ApoB and their ratios on clinical pregnancy rate.Results The body mass index(BMI) [(25.49±2.11)kg/m2 vs. (24.37±2.09)kg/m2], insulin resistance index (HOMA-IR) [(4.68±1.01) vs. (4.02±0.87)], low-density lipo-protein cholesterol (LDL-C) [(2.99±0.84)mmol/L vs. (2.51±0.63)mmol/L], ApoB level [(1.15±0.25)g/L vs. (0.93±0.21)g/L] and ApoB/ApoA1 ratio in the non pregnancy group were higher than those in the pregnancy group, while the proportion of two embryo transferswas lower than that in the pregnancy group (10.87% vs. 25.97%, P<0.05). The difference in serum ApoA1 levels between the two groups was not statistically significant (P>0.05). Logistic regression analysis showed that ApoB and ApoB/ApoA1 ratios were all associ-ated with the clinical pregnancy rate of HRT-FET in PCOS patients (P<0.05). Smooth curve fitting showed that the impact of ApoB on the clinical non pregnancy rate of HRT-FET in PCOS patients showed an increasing curve relationship. The effect of the ApoB/ApoA1ratio on the clinical pregnancy rate of HRT-FET in PCOS patients showed a curve relationship that first increases and then gradually flattens.Conclusions There is a certain correlation between ApoB and ApoB/ApoA1 ratios and the clinical pregnancy rate of HRT-FET in PCOS patients. Early monitoring of ApoB and ApoB/ApoA1 ratios may be beneficial for indicating changes in bed pregnancyrate. |
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