| 刘浩,黄铖铖,万小梅,等.血清腱生蛋白 C水平在早产儿支气管肺发育不良中的变化及临床意义[J].安徽医药,2026,30(11):2211-2216. |
| 血清腱生蛋白 C水平在早产儿支气管肺发育不良中的变化及临床意义 |
| Changes of serum Tenascin-C level in bronchopulmonary dysplasia in preterm infants and the clinical significance |
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| DOI：10.3969/j.issn.1009-6469.2026.11.017 |
| 中文关键词: 腱生蛋白 支气管肺发育不良 早产儿 极低出生体质量 标志物 |
| 英文关键词: Tenascin Bronchopulmonary dysplasia Preterm infants Very low birth weight Marker |
| 基金项目:安徽省高等学校科学研究项目( 2023AH051780) |
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| 中文摘要: |
| 目的探讨血清腱生蛋白 C(TNC)水平在早产儿支气管肺发育不良( BPD)中的变化以及临床意义。方法根据诊断结果将 94例胎龄 ≤32周的早产儿分为 BPD组( n=23)和非 BPD组( n=71)收集两组病儿的临床资料。采用酶联免疫吸附法( ELI-SA)检测病儿出生后第 1、14、28天血清 TNC水平。通过单因素和多因素，logistic回归分析早产儿发生 BPD的危险因素，通过受 |
| 英文摘要: |
| Objective To investigate the changes of serum Tenascin-C (TNC) level in bronchopulmonary dysplasia (BPD) in preterm infants and the clinical significance.Methods Ninety-four preterm infants with gestational age ≤32 weeks were categorized into BPD group (n=23) and non-BPD group (n=71) according to the diagnosis results. Clinical data of both groups were collected. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum TNC levels of the children on the 1st, 14th and 28th d after birth. The riskfactors for BPD in preterm infants were analyzed by univariate and multivariate logistic regression analyses, and the optimal thresholdof TNC as a predictor of BPD and its predictive efficacy were determined by receiver operating characteristic (ROC) curve. Results There were statistically significant differences in serum TNC levels of the non-BPD groupat day 1 postpartum (17.02±4.34)μg/L, day 14 postpartum(18.50±4.04)μg/L, and day 28postpartum (19.75±3.71)μg/L (P<0.001). The TNC level in the BPD group at day 14 postpar-tum (23.99±2.63)μg/L was significantly higher than that at day 1postpartum (16.99±3.49)μg/L, with a statistically significant difference(P<0.05). No statistically significant differences were observed between the two groups for TNC levels at day 1 postpartum[(16.99±3.49)μg/L vs. (17.02±4.34)μg/L] or day 28 postpartum(19.10±3.73)μg/L vs. (19.75±3.71)μg/L(P>0.05). However, the TNC level in the BPDgroup at day 14 postpartum (23.99±2.63)μg/L was significantly higher than that in the non-BPD group (18.50±4.04)μg/L(P<0.001). Multivariate logistic regression analysis identified gestational age and 14-day serum TNC as independent risk predictors for BPD in pre‐term infants. ROC analysis revealed that the area under the curve (AUC) for 14-day serum TNC alone and for 14-day serum TNC com-bined with gestational age were 0.88[95%CI:(0.80,0.96)] and 0.98[95%CI:(0.96,1.00)], respectively.Conclusion Serum TNC level is closely associated with BPD in preterm infants. Serum TNC at day 14 postpartum independently predicts BPD in preterm infants, poten-tially combining with gestational age may serve as an early predictive marker for BPD. |
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