| 姚佳欣,费素娟.血清炎症细胞因子水平与急性胰腺炎合并胸腔积液的关系[J].安徽医药,2026,30(11):2250-2254. |
| 血清炎症细胞因子水平与急性胰腺炎合并胸腔积液的关系 |
| Relationship between serum inflammatory cytokine levels and pleural effusion in acute pancreatitis |
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| DOI：10.3969/j.issn.1009-6469.2026.11.024 |
| 中文关键词: 急性胰腺炎 细胞因子 胸腔积液 白细胞介素 干扰素 肿瘤坏死因子 α |
| 英文关键词: Acute pancreatitis Cytokines Pleural effusion Interleukin Interferon Tumor necrosis factor-α |
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| 中文摘要: |
| 目的探讨血清炎症细胞因子水平与急性胰腺炎(AP)合并胸腔积液的关系。方法回顾性分析 2020年 6月至 2023年 5月徐州医科大学附属医院收治的 320例发病 48 h内住院的 AP病人临床资料，根据 AP病人住院期间是否发生胸腔积液，分为胸腔积液组与无胸腔积液组。收集病人住院期间的一般资料、影像学检查及 24 h内实验室检查结果。比较两组一般资料、 12种血清炎症细胞因子［包括白细胞介素( IL)-1β、IL-2、IL-4、IL-5、IL-6、IL-8、IL-10、IL-12p70、IL-17、干扰素( IFN)-γ、IFN-α、肿瘤坏死因子( TNF)-α］水平。细胞因子作为连续型自变量和顺序分类变量，采用多因素二元 logistic回归分析确定细胞因子与 AP合并胸腔积液的关系，计算优势比( OR)和 95%置信区间(CI)。受试者操作特征曲线(ROC曲线)用于评价细胞因子对 AP合并胸腔积液的预测价值。结果胸腔积液组病人血清 IL-1β［7.04(2.58，19.98)ng/L比 4.20(2.26，9.55)ng/L］、 IL-6［33.83(10.82，69.40)ng/L比 8.40(3.07，26.78)ng/L］、 IL-8［9.29(2.69，23.58)ng/L比 3.71(1.87，17.25)ng/L］和 IL-10［2.06(1.32，4.16)ng/L比 1.64(0.92，2.78)ng/L］水平显著高于无胸腔积液组( P<0.05)。血清高水平的 IL-1β、IL-6、IL-8和 IL-10与各自的最低四分位数区间(Q1)相比，发生胸腔积液的风险增加( P<0.05)。在 ROC曲线分析中，血清 IL-1β、IL-6、IL-8和 IL-10对胸腔积液的发生有预测价值。其中， IL-6预测价值最佳( AUC为 0.70)。结论血清高水平 IL-1β、IL-6、IL-8和 IL-10是 AP合并胸腔积液的独立危险因素。入院早期血清 IL-6水平可作为预测 AP合并胸腔积液的良好指标。 |
| 英文摘要: |
| Objective To investigate the relationship between serum inflammatory cytokine levels and pleural effusion in patientswith acute pancreatitis (AP).Methods A retrospective analysis was conducted on the clinical data of 320 patients with AP who wereadmitted to the Affiliated Hospital of Xuzhou Medical University within 48 hours of onset from June 2020 to May 2023. According towhether the patients with AP developed pleural effusion during hospitalization, they were divided into pleural effusion group and non-pleural effusion group. The general data, imaging findings and laboratory test results within 24 hours of admission were collected. De-mographic data and the levels of 12 serum inflammatory cytokines [including interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, interferon (IFN)-γ, IFN-α, and tumor necrosis factor (TNF)-α] were compared between the two groups. Cytokines wereused as continuous independent variables and ordinal categorical variables. Multivariate binary logistic regression analysis was per-formed to determine the relationship between cytokines and AP complicated with pleural effusion, and odds ratios (OR) and 95% confi-dence intervals (CI) were calculated. Receiver operating characteristic (ROC) curve was used to evaluate the predictive value of cyto-kines for AP complicated with pleural effusion. Results The serum IL-1β [7.04 (2.58, 19.98) ng/L vs. 4.20 (2.26, 9.55) ng/L], IL-6 [33.83 (10.82,69.40)ng/L vs. 8.40 (3.07,26.78) ng/L], IL-8 [9.29 (2.69,23.58) ng/L vs. 3.71 (1.87,17.25) ng/L] and IL-10 [2.06 (1.32, 4.16) ng/L vs. 1.64 (0.92,2.78) ng/L] levels of patients in the pleural effusion group were significantly higher than those in the non-pleu-ral effusion group (P<0.05). Elevated serum levels of IL-1β, IL-6, IL-8 and IL-10 showed an increased risk of pleural effusion com-pared with their respective lowest quartiles (Q1) (P<0.05). ROC curve analysis showed that serum IL-1β, IL-6, IL-8 and IL-10 levels had predictive value for the occurrence of pleural effusion, among which IL-6 demonstrated the best predictive performance (AUC= 0.70).Conclusions Elevated serum levels of IL-1β, IL-6, IL-8 and IL-10 are independent risk factors for AP complicated with pleural effusion. Early serum IL-6 level upon admission may serve as a good predictor for AP complicated with pleural effusion. |
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