| 赵杰,沈海林,张绍星.共激活蛋白相关精氨酸甲基转移酶 1和 WD重复域蛋白 5在宫颈癌组织中表达及其与临床病理特征和预后的相关性[J].安徽医药,2026,30(11):2255-2260. |
| 共激活蛋白相关精氨酸甲基转移酶 1和 WD重复域蛋白 5在宫颈癌组织中表达及其与临床病理特征和预后的相关性 |
| Expression of coactivator-associated arginine methyltransferase 1 and WD repeat-containing protein 5 in cervical cancer tissue and their association with patients'clinical andpathological characteristics and prognosis |
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| DOI：10.3969/j.issn.1009-6469.2026.11.025 |
| 中文关键词: 宫颈肿瘤 共激活蛋白相关精氨酸甲基转移酶 1 WD重复域蛋白 5 临床病理特征 预后 |
| 英文关键词: Uterine cervical neoplasms Coactivator-associated arginine methyltransferase 1 WD repeat-containing protein 5 Clinical pathological features Prognosis |
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| 目的探讨共激活蛋白相关精氨酸甲基转移酶 1(CARM1)和 WD重复域蛋白 5(WDR5)在宫颈癌( CC)组织中的表达及其与临床病理特征及预后的关系。方法前瞻性研究 2017年 3月至 2019年 3月平顶山市第一人民医院收治的 108例宫颈癌病人，收集癌组织、癌旁组织。采用免疫组织化学染色( IHC)检测组织中 CARM1和 WDR5表达，采用 Kaplan-Meier生存曲线评估 CARM1和 WDR5表达状态与宫颈癌病人生存率的关系；进一步采用 Cox回归分析两指标对宫颈癌病人预后的独立影响。结果宫颈癌组织 CARM1阳性表达率为 74.07%(80/108)WDR5阳性表达率为 82.41%(89/108)，均明显高于癌旁组织 19%(11/108)和 6.48%(7/108)(P<0.05)； CARM1在国际妇产科联盟，(FIGO)Ⅱa期、淋巴结转移、低分化病人中的阳性表达率分别为 84.31%(43/51)、 84.78%(39/46)、 84.00%(42/50)，高于 FIGO Ⅰa~Ⅰb期的 64.91%(37/57)、无淋巴结转移的 66.13%(41/62)、中高分化 65.52%(38/58)(P<0.05)； WDR5在 FIGO Ⅱa期、淋巴结转移、低分化病人中的阳性表达率分别为 92.16%(47/51)、 93.48%(43/46)、 92.00%(46/50)高于 FIGO Ⅰa~Ⅰb期的 73.68%(42/57)、无淋巴结转移的 74.19%(46/62)、中高分化 74.14%(43/58)(P<0.05)； CARM1阳性表达，病人 5年生存率为 65.00%(52/80)，中位生存时间为 37个月，低于阴性表达病人的 85.71%(24/28)和 55个月( P<0.05)； WDR5阳性表达病人 5年生存率为 66.29%(59/89)，中位生存时间为 39个月，低于阴性表达病人的 89.47%(17/19)和 58个月( P<0.05)；多因素 Cox回归分析显示， 达［95%CI:2.22)WDR5阳性表CARM1阳性表HR=1.57，(1.11， ］、 达［( HR=2.05，95%CI:(1.24，3.37)］、 FIGO分期为 Ⅱa期［HR=1.06，95%CI:(1.00，1.11)］、淋巴结转移［HR=1.17，95%CI:(1.04，1.32)］、分化程度为低分化［HR=1.25，95%CI:(1.06，1.47)］是宫颈癌病人预后死亡的危险因素( P<0.05)。结论 CARM1和 WDR5在宫颈癌组织中阳性表达率均明显升高，并与病人临床病理特征(淋巴结转移)及较低生存率有关。 |
| 英文摘要: |
| Objective To investigate the expression of coactivator-associated arginine methyltransferase 1 (CARM1) and WD repeat-containing protein 5 (WDR5) in cervical cancer (CC) tissue and their association with patients'clinical andpathological characteristicsand prognosis. Methods A total of 108 CC patients admitted to First People's Hospital of Pingdingshan City from March 2017 toMarch 2019 were gathered, and the cancer tissue and adjacent tissue were collected. Immunohistochemistry (IHC) was used to detectCARM1 and WDR5 expression in tissues. Kaplan-Meier survival curves were used to assess the relationship between CARM1 andWDR5 expression status and survival rates in patients with CC; Cox regression analysis was further employed to examine the indepen-dent prognostic impact of these two markers on patient outcomes. Results The CARM1-positive expression rate in CC tissue was 74.07% (80/108), and the WDR5-positive expression rate was 82.41% (89/108), both of which were significantly higher than those inperitumoral tissue [19% (11/108) and 6.48% (7/108), respectively] (P<0.05). the positive expression rates of CARM1 in patients withFIGO Stage Ⅱa, lymph node metastasis, and poorly differentiated tumors were 84.31% (43/51), 84.78% (39/46), and 84.00% (42/50),respectively, which were higher than those in patients with FIGO stage Ⅰa-Ⅰb (64.91%, 37/57), those without lymph node metastasis 66.13%(41/62), and those with moderate-to-high differentiation 65.52%(38/58) (P<0.05);the positive expression rates of WDR5 in pa-tients with FIGO stage Ⅱ a, lymph node metastasis, and low differentiation were 92.16%(47/51), 93.48%(43/46), and 92.00%(46/50),respectively, which were higher than those in patients with FIGO stage Ⅰa-Ⅰb 73.68%(42/57), those without lymph node metastasis 74.19%(46/62), and those withmoderate-to-high differentiation 74.14%(43/58) (P<0.05). The 5-year survival rate of CARM1-positive patients was 65.00% (52/80) and the median survival time was 37 months, which were lower than those of CARM1-negative patients [85.71% (24/28) and 55 months] (P<0.05), The 5-year survival rate of WDR5-positive patients was 66.29% (59/89) and the median sur-vival time was 39 months, which were lower than those of WDR5-negative patients[89.47% (17/19) and 58 month] (P<0.05). Multivari-ate Cox regression analysis showed thatCARM1 positive expression [HR=1.57,95%CI=(1.11,2.22)], WDR5 positive expression [HR= 2.05,95%CI:(1.24,3.37)],and FIGO stage Ⅱa [HR=1.06,95%CI:(1.00,1.11)], lymph node metastasis [HR=1.17, 95% CI:(1.04,1.32), and low differentiation [HR=1.25, 95%CI=(1.06,1.47)] were risk factors for mortality in CC patients (P<0.05).Conclusion The positive ex-pression rates of CARM1 and WDR5 in CC tissues are obviously increased, and are related to the clinical pathological features(lymphnode metastasis) and lower survival rates of patients. |
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