| 冯小伟,王佳,杨荣秉,等.肺腺癌组织中长链非编码 RNA癌易感性候选基因 9、微 RNA-383-5p的表达及与肺腺癌进展和预后的关系[J].安徽医药,2026,30(11):2276-2280. |
| 肺腺癌组织中长链非编码 RNA癌易感性候选基因 9、微 RNA-383-5p的表达及与肺腺癌进展和预后的关系 |
| Expression of long non-coding RNA cancer susceptibility candidate 9 and microRNA-383-5p in lung adenocarcinoma tissues and their relationship with disease progression and prognosis |
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| DOI：10.3969/j.issn.1009-6469.2026.11.029 |
| 中文关键词: 肺腺癌 长链非编码 RNA癌易感性候选基因 9 微 RNA-383-5p 预后 |
| 英文关键词: Lung adenocarcinoma Long non-coding RNA cancer susceptibility candidate 9 MicroRNA-383-5p Prognosis |
| 基金项目:河北省医学科学研究重点课题( 20171134) |
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| 中文摘要: |
| 目的探讨肺腺癌组织中长链非编码 RNA癌易感性候选基因 9(lncRNA CASC9)、微 RNA-383-5p(miR-383-5p)的表达情况及其与肺腺癌进展和预后的关系。方法前瞻性研究 2017年 3月至 2019年 4月在邯郸市中心医院进行手术切除治疗的 271例肺腺癌病人，收集手术切除的肺腺癌组织和癌旁组织，测定组织中 lncRNA CASC9、miR-383-5p的表达；采用 Kaplan-Meier曲线分析 lncRNA CASC9、miR-383-5p表达与肺腺癌病人预后的关系；采用 Cox回归分析影响病人预后的因素。结果癌组织 miR-383-5p表达水平［(0.74±0.12)/U6］低于癌旁组［(1.03±0.32)/U6］，lncRNA CASC9表达水平［(2.65±0.68)/GAPDH］高于癌旁组织［(1.05±0.35)/GAPDH］(P<0.05)； lncRNA CASC9、miR-383-5p表达水平与病人肿瘤长径、 TNM分期、分化程度、淋巴结转移相关( P<0.05)； lncRNA CASC9高表达组病人生存率( 44.0%)低于 lncRNA CASC9低表达组( 75.9%)miR-383-5p高表达组病人生存率( 78.7%)高于 miR-383-5p低表达组( 41.5%)(log-rank χ2=27.50、34.93，均 P<0.001)；多因素 Cox回，归分析表明， lncRNA CASC9高表达［HR=2.12，95%CI:(1.20，3.76)］、 miR-383-5p低表达［HR=2.04，95%CI:(1.15，3.60)］是影响肺腺癌病人预后不良的危险因素( P<0.05)。结论 lncRNA CASC9高表达、 miR-383-5p低表达可能与肺腺癌的发生发展及预后有关，有望成为肺腺癌潜在的研究靶点。 |
| 英文摘要: |
| Objective To investigate the expression of long non-coding RNA cancer susceptibility candidate 9 (lncRNA CASC9) and microRNA-383-5p (miR-383-5p) in lung adenocarcinoma tissues and their relationship with the progression and prognosis of lung ade-nocarcinoma.Methods A total of 271 patients with lung adenocarcinoma who underwent surgical resection in Handan Central Hospi-tal from March 2017 to April 2019 were enrolled, and the surgically resected lung adenocarcinoma tissues and adjacent paracanceroustissues were collected. The expression levels of lncRNA CASC9 and miR-383-5p in tissues were measured. Kaplan-Meier curves were used to analyze the relationship between the expression of lncRNA CASC9, miR-383-5p and the prognosis of patients with lung adeno-carcinoma. Cox regression analysis was performed to identify factors affecting poor prognosis.Results The expression level of miR-383-5p in cancer tissues [(0.74±0.12)/U6] was significantly lower than that in adjacent paracancerous tissues [(1.03±0.32)/U6], whilethe expression level of lncRNA CASC9 [(2.65±0.68)/GAPDH] was significantly higher than that in adjacent paracancerous tissues[(1.05±0.35)/GAPDH] (P<0.05). The expression levels of lncRNA CASC9 and miR-383-5p were closely correlated with tumor size, TNM stage, degree of differentiation, and lymph node metastasis (P<0.05). The survival rate of patients in the lncRNA CASC9 high-ex-pression group (44.0%) was lower than that in the low-expression group (75.9%), and the survival rate of patients in the miR-383-5p high-expression group (78.7%) was higher than that in the low-expression group (41.5%) (log-rank χ2=27.50, 34.93; all P<0.001). Mul-tivariate Cox regression analysis revealed that high expression of lncRNA CASC9 [HR=2.12, 95%CI:(1.20, 3.76)] and low expression of miR-383-5p [HR=2.04, 95%CI:(1.15, 3.60)] were risk factors for poor prognosis in patients with lung adenocarcinoma (P<0.05).Conclu. sion High expression of lncRNA CASC9 and low expression of miR-383-5p may be associated with the occurrence, progression andprognosis of lung adenocarcinoma, and they are expected to become potential research targets for lung adenocarcinoma. |
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