| 王杰,刘永强.罕见胃肝样腺癌接受新辅助化疗 1例[J].安徽医药,2026,30(11):2289-2293. |
| 罕见胃肝样腺癌接受新辅助化疗 1例 |
| Hepatoid adenocarcinoma of the stomach:a case report of neoadjuvant chemotherapy |
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| DOI：10.3969/j.issn.1009-6469.2026.11.032 |
| 中文关键词: 胃肿瘤 腺癌 胃肝样腺癌 甲胎蛋白 化疗 |
| 英文关键词: Stomach neoplasms Adenocarcinoma Hepatoid adenocarcinoma of the stomach Alpha-fetoprotein Chemotherapy |
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| 中文摘要: |
| 目的提高对胃肝样腺癌( HAS)的认识，为提高该病的临床诊治水平提供参考。方法回顾性分析内蒙古医科大学附属医院胃肠外科收治的 1例老年男性 HAS病人的临床资料及诊疗经过，并复习国内外有关 HAS的文献。结果男， 66岁，因“间断腹痛伴反酸、嗳气 3月余”于 2023年 8月 2日入院。根据胃镜病理活检、全腹部增强 CT、血清肿瘤标志物检查结果明确为 HAS，通过新辅助化疗后行手术切除，近期随访后治疗效果满意。结论 HAS为临床罕见的胃恶性肿瘤，临床症状和体征无特异性，临床不易早期发现，且易误诊为肝癌，胃镜和影像学有助于诊断，病理 +免疫组化是确诊的唯一方法。明确诊断的早期病人应积极手术，进展期病人可先行新辅助化疗后再行手术。 |
| 英文摘要: |
| Objective To raise awareness of hepatoid adenocarcinoma of the stomach (HAS) and provide a reference for improvingthe clinical diagnosis and treatment of this disease.Methods A retrospective analysis was performed on the clinical data and thera-peutic course of an elderly male patient with HAS admitted to the Department of Gastrointestinal Surgery, Affiliated Hospital of InnerMongolia Medical University, supplemented by a review of domestic and international literature on HAS.Results The patient, a 66-year-old male, was admitted on August 2, 2023, with chief complaints of intermittent abdominal pain accompanied by acid regurgitationand belching for over 3 months. Diagnosis of HAS was confirmed through gastroscopic pathological biopsy, whole-abdominal contrast-enhanced computed tomography (CT), and serum tumor marker tests. The patient underwent surgical resection following neoadjuvantchemotherapy, and recent follow-up demonstrated satisfactory therapeutic outcomes.Conclusions HAS is a clinically rare gastric ma-lignancy with nonspecific clinical signs and symptoms, making early detection challenging and often leading to misdiagnosis as hepato-cellular carcinoma. Gastroscopy and imaging studies aid in diagnosis, while pathological examination combined with immunohistochem-istry remains the only definitive diagnostic method. For patients with a confirmed early-stage diagnosis,active surgical intervention isrecommended, whereas those with advanced disease may benefit from neoadjuvant chemotherapy prior to surgery. |
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