| 王雅茜,李文文,孙朋,等.胃底腺黏膜型腺癌合并胃高级别上皮内瘤变 1例[J].安徽医药,2026,30(11):2298-2301. |
| 胃底腺黏膜型腺癌合并胃高级别上皮内瘤变 1例 |
| Gastric adenocarcinoma of the fundic gland mucosa type complicated with high-grade intraepithelial neoplasia: a case report |
| |
| DOI：10.3969/j.issn.1009-6469.2026.11.034 |
| 中文关键词: 胃肿瘤 胃底腺黏膜型腺癌 胃高级别上皮内瘤变 免疫组织化学染色 |
| 英文关键词: Stomach neoplasm Gastric adenocarcinoma of the fundic gland mucosa type Gastric high-grade intraepithelial neo-plasia Immunohistochemistry staining |
| 基金项目:山东省自然科学基金联合基金项目( ZR2022LSW004)；山东省医药卫生科技项目( 202304010688)；潍坊医学院附属医院医学研究培育基金项目( 2021wyfyzjj15) |
|
| 摘要点击次数: 0 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的提高对胃底腺黏膜型腺癌( GA-FGM)的临床特点、内镜表现、病理特点、诊断及治疗的认识。方法回顾性分析 2021年 12月山东第二医科大学附属医院收治的 1例 GA-FGM合并胃高级别上皮内瘤变( HGIN)病人的临床病理资料，结合相关文献进行系统复习。结果病人因“腹痛 1个月余”入住。胃镜检查示在幽门螺杆菌( Hp)感染背景下，胃窦小弯见一扁平隆起，活检病理示部分腺上皮中度异型增生，胃体上段后壁见一黏膜下隆起，超声胃镜示低回声团块，似起源于黏膜肌层。行内镜黏膜下剥离术 +内镜下全层切除术，术后病理示胃窦小弯局灶高级别上皮内瘤变，胃体上段后壁胃底腺型胃癌，完善免疫组织化学染色( IHC)示黏蛋白( MUC)2(.)、 MUC5AC(+)、 MUC6(+)、三磷酸腺苷( ATP)(+)、胃蛋白酶原 Ⅰ(pepsinogen-1)(+)、核增殖抗原( Ki-67)(+5%)，符合胃底腺黏膜型胃癌。术后 3个月及近期随访复查胃镜恢复可。结论 GA-FGM合并胃 HGIN相对少见，通过内镜下表现及病理尽早明确诊断，综合判断、制定合理治疗方案，改善病人预后及生活质量。 |
| 英文摘要: |
| Objective To improve the understanding of clinical features, endoscopic manifestations, pathological features, diagnosisand treatment of gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM).Methods The clinicopathological data of a pa-tient diagnosed with GA-FGM complicated with gastric high-grade intraepithelial neoplasia (HGIN) were retrospectively analyzed in Af-filiated Hospital of Shandong Second Medical University at December 2021, and the relevant literature was reviewed.Results The pa-tient was admitted with "abdominal pain for more than 1 month".Gastroscopy revealed a flat bulge in the minor curvature of the gastricantrum in the context of Helicobacter pylori infection, and biopsy pathology revealed moderate dysplasia of some glandular epithelium.Meanwhile, gastroscopy also showed a submucosal bulge in the posterior wall of the upper part of the stomach and ultrasound gastrosco-py showed a hypoechoic mass that seemed to have originated in the mucosal muscle layer. Both endoscopic complete resection and en-doscopic submucosal dissection were carried out. Postoperative pathology revealed focal high-grade intraepithelial neoplasia in the mi-nor curvature of the gastric antrum. In the posterior wall of the upper part of the stomach, immunohistochemical staining showed MUC2(.), MUC5AC (+), MUC6 (+), ATP (+), pepsinogen-1 (+), Ki-67 (+ 5%) , which was consistent with gastric fundus mucosal type gastric cancer. Recovery from a gastroscopy was feasible at the most recent follow-up and three months following surgery.Conclusions GA-FGM combined with gastric HGIN is relatively rare. The prognosis and quality of life of patients can be greatly enhanced by early iden-tification by endoscopic symptoms and pathology, thorough assessment, and the development of a realistic treatment strategy. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
