| 万庆芝,李英焕,唐淮云.补肾活血法对肾虚血瘀型卵巢储备功能减退不孕症病人卵子质量及体外受精 -胚胎移植助孕结局的影响[J].安徽医药,2026,30(11):2315-2319. |
| 补肾活血法对肾虚血瘀型卵巢储备功能减退不孕症病人卵子质量及体外受精 -胚胎移植助孕结局的影响 |
| Effect of Bushen Huoxue therapy on oocyte quality and IVF-ET outcomes in infertility patients with diminished ovarian reserve of kidney deficiency and blood stasis type |
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| DOI：10.3969/j.issn.1009-6469.2026.11.038 |
| 中文关键词: 不孕症 卵巢储备功能减退 肾虚血瘀型 补肾活血法 体外受精 -胚胎移植 胚胎质量 |
| 英文关键词: Infertility Diminished ovarian reserve Kidney deficiency and blood stasis Bushen Huoxue therapy In vitro fertil-ization-embryo transfer Embryo quality |
| 基金项目:连云港市妇幼健康科研项目( F202107)；连云港市卫生健康科技项目( QN202211)；连云港市妇幼保健院青年英才培养基金项目( KY202406) |
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| 中文摘要: |
| 目的观察补肾活血法对肾虚血瘀型卵巢储备功能减退(DOR)不孕症病人卵子质量及体外受精 -胚胎移植(IVF-ET)助孕结局的影响。方法前瞻性研究。将 2022年 1月至 2023年 12月于连云港市妇幼保健院行 IVF-ET助孕治疗的肾虚血瘀型 DOR不孕症病人 79例以随机数字表法分为两组:对照组(n=39)和治疗组(n=40)均采用拮抗剂方案促排卵。治疗组病人在进入 IVF促排周期前 1个月的月经期第 1~3天开始服用补肾活血方，每日 1剂，水煎至，400 mL，分早晚 2次温服，服用至取卵日，植后 2周验孕；对照组只接受 IVF-ET治疗。比较两组病人促性腺激素( Gn)总量及使用时间，人绒毛膜促性腺激素( HCG)日雌移二醇、黄体生成素( LH)水平，穿刺卵泡数、获卵数、受精率、卵裂率、第 3天( D3)优质胚胎率、无可移植胚胎率、胚胎冷冻率、临床妊娠率、鲜胚移植妊娠率、冻胚移植妊娠率、总流产率差异。结果治疗组穿刺卵泡数、获卵数、受精率、卵裂率、 D3优质胚胎率［66.67%(68/102)比 48.78%(20/41)］、临床妊娠率［53.13%(17/32)比 26.92%(7/26)］均高于对照组( P<0.05)，而胚胎冷冻率均低于对照组( P<0.05)两组间 Gn时间、 Gn总量、 HCG日雌二醇水平、 HCG日 LH水平、无可移植胚胎率、鲜胚妊娠率、冻胚妊娠率、总流产率差异无统计，学意义( P>0.05)两组间安全性指标:血红蛋白、血肌酐、丙氨酸氨基转移酶、天冬氨酸氨基转移酶均差异无统计学意义( P>0.05)。结论补肾活，血法能增加肾虚血瘀型 DOR不孕症病人获卵数，提高受精率、卵裂率、胚胎质量和临床妊娠率。 |
| 英文摘要: |
| Objective To observe the effect of Bushen Huoxue therapy (a traditional Chinese medicine method for toinfying the kid-ney and activating blood circulation) on oocytes and in vitro fertilization-embryo transfer (IVF-ET) outcomes in infertile patients with di-minished ovarian reserve (DOR) of kidney deficiency and blood stasis type.Methods This prospective study included 79 infertility pa-tients with DOR of kidney deficiency and blood stasis type who underwent IVF-ET treatment at Lianyungang Maternal and ChildHealth Hospital from January 2022 to December 2023. Patients were randomly assigned to two groups using a random number table:the control group (n=39) and the treatment group (n=40). Both groups received ovarian stimulation using a gonadotropin-releasing hor-mone (GnRH) antagonist protocol. Patients in the treatment group began taking the Bushen Huoxue formula on days 1-3 of the menstru-al cycle, one month before entering the IVF stimulation cycle. The formula was administered as one dose per day, decocted in water to afinal volume of 400 mL, and taken warm twice daily (morning and evening). Treatment continued until the day of oocyte retrieval, fol-lowed by pregnancy testing two weeks after embryo transfer. The control group received only IVF-ET treatment. The two groups werecompared with respect to total gonadotropin (Gn) dose and duration, serum estradiol (E2) and luteinizing hormone (LH) levels on theday of human chorionic gonadotropin (hCG) administration, number of follicles punctured, number of oocytes retrieved, fertilizationrate, cleavage rate, day 3 (D3) high-quality embryo rate, non-transferable embryo rate, embryo cryopreservation rate, clinical pregnancyrate, fresh embryo transfer pregnancy rate, frozen embryo transfer pregnancy rate, and total miscarriage rate.Results The treatment group had significantly higher numbers of punctured follicles and oocytes retrieved, higher fertilization and cleavage rate, a higher D3high-quality embryo rate [66.67% (68/102) vs. 48.78% (20/41)], and a higher clinical pregnancy rate [53.13% (17/32) vs. 26.92% (7/ 26)] than the control group (P<0.05), whereas the embryo cryopreservation rates was significantly lower than that in the control group (P< 0.05). No significant difference were observed between the two groups in Gn duration, total Gn dose, E2 or LH levels on the day of hCGadministration, non-transferable embryo rate, fresh embryo transfer pregnancy rate, frozen embryo transfer pregnancy rate, or total mis-carriage rate (P>0.05). Safety parameters, including hemoglobin, serum creatinine, alanine aminotransferase, and aspartate aminotrans-ferase, did not differ significantly between the two groups (P>0.05).Conclusion Bushen Huoxue therapy can increase the number ofoocytes retrieved and improve fertilization rate, cleavage rate, embryo quality, and clinical pregnancy rate in infertile patients with DORof kidney deficiency and blood stasis type. |
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