| 罗强,叶拥宏.国家专利中药复方治疗慢性鼻炎用药规律研究[J].安徽医药,2026,30(11):2324-2332. |
| 国家专利中药复方治疗慢性鼻炎用药规律研究 |
| Prescription patterns within patented traditional Chinese medicine formulas for chronic rhinitis |
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| DOI：10.3969/j.issn.1009-6469.2026.11.040 |
| 中文关键词: 中药 复方药 专利药 慢性鼻炎 数据挖掘 用药规律 |
| 英文关键词: Chinese materia medica Compound medicine Patent drugs Hronic rhinitis Data mining Prescription patterns |
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| 中文摘要: |
| 目的采用数据挖掘方法分析国家专利中药复方治疗慢性鼻炎( CR)的用药规律，为临床辨证处方提供参考依据。方法 2025年 5月通过国家知识产权局专利检索及分析系统获取近 30年来治疗 CR的中药复方专利，借助 Excel建立复方数据库，利用 R语言对符合条件的数据进行频次统计、高频药物功效分析、复方相似性分析、性味归经分析、关联规则分析、核心中药共现分析及高频药物聚类分析。结果纳入治疗 CR的中药复方 165个，涉及药物 336味。高频中药有 29味，使用频次排名前 10的药物分别为辛夷、苍耳子、白芷、甘草、川芎、防风、黄芪、黄芩、细辛、桔梗。药物功效以解表药、补虚药、清热药为主。性味以寒性、苦味为主，多归肺经。关联规则分析得到 13组药对、 43组角药组合。核心中药共现网络由 23味中药组成。高频中药聚类分析得到 8个潜在聚类方。结论国家专利中药复方治疗 CR采用以疏风散寒、清热宣肺、健脾益肺、行气活血为主的治法，多选用辛夷、苍耳子、白芷等核心药物，其关联组合与聚类方可直接用于配伍组方，为临床用药提供参考。 |
| 英文摘要: |
| Objective To analyze the prescription patterns within patented traditional Chinese medicine (TCM) formulas for chronicrhinitis (CR) using data mining methods, and to provide references for clinical syndrome differentiation and prescription strategies.Methods TCM formula patents for treating CR from the past three decades were retrieved from the Patent Search and Analysis Sys-tem of the China National Intellectual Property Administration (CNIPA)in May 2025.A database was constructed using Microsoft Excel,and the eligible data were subjected to comprehensive analyses using the R programming language. These analyses included frequencystatistics, efficacy analysis of frequently used Chinese materia medica (CMM), and formula similarity analysis. Additional analyses en-compassed statistics on herbal properties(nature, flavor, and channel tropism), association rule mining, core CMM co-occurrence analy-sis, and cluster analysis of high-frequency CMM.Results A total of 165 patented formulas, comprising 336 individual herbs, were in-cluded in the analysis. Twenty-nine high-frequency herbs were identified, with the top ten being Magnoliae Flos, Xanthii Fructus, An-gelicae Dahuricae Radix, Glycyrrhizae Radix et Rhizoma, Chuanxiong Rhizoma, Saposhnikoviae Radix, Astragali Radix, ScutellariaeRadix, Asari Radix et Rhizoma, and Platycodonis Radix. In terms of efficacy, the herbs were primarily classified as exterior-releasing medicinals, tonic medicinals, and interior heat-clearing medicinals. The dominant herbal properties were determined to be cold in na-ture and bitter in flavor, with a primary tropism to the Lung meridian. Through association rule analysis, 13 significant herb pairs and43 three-herb combinations were identified. Furthermore, a core co-occurrence network was constructed from 23 key herbs, and 8 po-tential core formulas were revealed by cluster analysis.Conclusions It was concluded that the treatment of CR with patented TCM for-mulas is primarilybased on therapeutic methods such as dispersing wind and expelling cold, clearing heat and ventilating the lung,strengthening the spleen and tonifying the lung, and promoting qi circulation and activating blood.Core herbs,including Magnoliae Flos,Xanthii Fructus, and Angelicae Dahuricae Radix, are frequently selectedto achieve these therapeutic effects. The identified herb associ-ations and clustered formulas provide a valuable reference for contemporary clinical practice and the development of new prescriptions. |
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